Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
AMF_529Called by Glimmer 2; Conserved hypothetical protein called by Glimmer 2; psort: bacterial cytoplasm --- Certainty= 0.161(Affirmative); COG0316 Uncharacterized ACR. (146 aa)    
Predicted Functional Partners:
nifS-2
Putative cystine defulfurase (nifS-like protein); Duplicated gene; Similar to AMF_489; psort: bacterial inner membrane --- Certainty= 0.119(Affirmative); COG1104 cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes.
  
 
 0.919
nifU
Iron-sulfur cofactor synthesis protein (nifU); A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters.
  
 
 0.881
nuoI
NADH dehydrogenase I chain I (nuoI); NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.
  
  
 0.844
lepB
Signal peptidase I (lepB); Psort: bacterial inner membrane --- Certainty= 0.147(Affirmative); COG0681 LepB signal peptidase I; Belongs to the peptidase S26 family.
       0.829
nifS
Cysteine desulfurase (nifS) (duplicated gene); Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins.
  
 
 0.805
AMF_487
Called by Glimmer 2; Conserved hypothetical protein called by Glimmer 2; psort: bacterial cytoplasm --- Certainty= 0.215(Affirmative); COG0316 Uncharacterized ACR; Belongs to the HesB/IscA family.
 
    0.796
AMF_881
Called by Glimmer 2; Conserved hypothetical protein called by Glimmer 2; psort: bacterial cytoplasm --- Certainty= 0.318(Affirmative); COG0354 Predicted aminomethyltransferase related to GcvT.
  
 
 0.756
hscB
Chaperone protein (hscB); Psort: bacterial cytoplasm --- Certainty= 0.094(Affirmative); COG1076 DjlA DnaJ-domain-containing proteins 1.
  
 
 0.717
AMF_868
Called by Glimmer 2; Conserved hypothetical protein called by Glimmer 2; psort: bacterial cytoplasm --- Certainty= 0.318(Affirmative); COG0694 Thioredoxin-like proteins and domains.
  
 
 0.676
grxC2
Glutaredoxin-like protein GRLA (grxC2); Psort: bacterial cytoplasm --- Certainty= 0.297(Affirmative); Belongs to the glutaredoxin family. Monothiol subfamily.
  
 0.562
Your Current Organism:
Anaplasma marginale
NCBI taxonomy Id: 320483
Other names: A. marginale str. Florida, Anaplasma marginale str. Florida, Anaplasma marginale strain Florida
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