| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| clpA | guaA | AMF_538 | AMF_897 | ATP-dependent clp protease ATP-binding subunit (clpA); Psort: bacterial cytoplasm --- Certainty= 0.164(Affirmative); COG0542 ClpA ATPases with chaperone activity, ATP-binding subunit; Belongs to the ClpA/ClpB family. | GMP synthase (glutamine-hydrolyzing) (guaA); Catalyzes the synthesis of GMP from XMP. | 0.547 |
| clpA | typA | AMF_538 | AMF_537 | ATP-dependent clp protease ATP-binding subunit (clpA); Psort: bacterial cytoplasm --- Certainty= 0.164(Affirmative); COG0542 ClpA ATPases with chaperone activity, ATP-binding subunit; Belongs to the ClpA/ClpB family. | GTP-binding protein TypA (typA); Psort: bacterial inner membrane --- Certainty= 0.157(Affirmative); COG1217 TypA predicted membrane GTPase involved in stress response. | 0.631 |
| coxB | rpoB | AMF_766 | AMF_194 | Cytochrome c oxidase subunit II (coxB); Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B). | RNA polymerase beta subunit (rpoB); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.546 |
| coxB | typA | AMF_766 | AMF_537 | Cytochrome c oxidase subunit II (coxB); Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B). | GTP-binding protein TypA (typA); Psort: bacterial inner membrane --- Certainty= 0.157(Affirmative); COG1217 TypA predicted membrane GTPase involved in stress response. | 0.690 |
| engA | guaA | AMF_593 | AMF_897 | GTP-binding protein (engA); GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family. | GMP synthase (glutamine-hydrolyzing) (guaA); Catalyzes the synthesis of GMP from XMP. | 0.579 |
| engA | rplA | AMF_593 | AMF_191 | GTP-binding protein (engA); GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family. | Ribosomal protein L1 (rplA); Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release. | 0.445 |
| engA | rpoB | AMF_593 | AMF_194 | GTP-binding protein (engA); GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family. | RNA polymerase beta subunit (rpoB); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.403 |
| engA | tsf | AMF_593 | AMF_586 | GTP-binding protein (engA); GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family. | Translation elongation factor EF-Ts (tsf); Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome. Belongs to the EF-Ts family. | 0.493 |
| engA | typA | AMF_593 | AMF_537 | GTP-binding protein (engA); GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family. | GTP-binding protein TypA (typA); Psort: bacterial inner membrane --- Certainty= 0.157(Affirmative); COG1217 TypA predicted membrane GTPase involved in stress response. | 0.742 |
| guaA | clpA | AMF_897 | AMF_538 | GMP synthase (glutamine-hydrolyzing) (guaA); Catalyzes the synthesis of GMP from XMP. | ATP-dependent clp protease ATP-binding subunit (clpA); Psort: bacterial cytoplasm --- Certainty= 0.164(Affirmative); COG0542 ClpA ATPases with chaperone activity, ATP-binding subunit; Belongs to the ClpA/ClpB family. | 0.547 |
| guaA | engA | AMF_897 | AMF_593 | GMP synthase (glutamine-hydrolyzing) (guaA); Catalyzes the synthesis of GMP from XMP. | GTP-binding protein (engA); GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family. | 0.579 |
| guaA | gyrA | AMF_897 | AMF_273 | GMP synthase (glutamine-hydrolyzing) (guaA); Catalyzes the synthesis of GMP from XMP. | DNA gyrase subunit A (gyrA); A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.553 |
| guaA | polA | AMF_897 | AMF_914 | GMP synthase (glutamine-hydrolyzing) (guaA); Catalyzes the synthesis of GMP from XMP. | DNA polymerase I (polA); In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.703 |
| guaA | rplA | AMF_897 | AMF_191 | GMP synthase (glutamine-hydrolyzing) (guaA); Catalyzes the synthesis of GMP from XMP. | Ribosomal protein L1 (rplA); Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release. | 0.985 |
| guaA | rpoB | AMF_897 | AMF_194 | GMP synthase (glutamine-hydrolyzing) (guaA); Catalyzes the synthesis of GMP from XMP. | RNA polymerase beta subunit (rpoB); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.961 |
| guaA | tsf | AMF_897 | AMF_586 | GMP synthase (glutamine-hydrolyzing) (guaA); Catalyzes the synthesis of GMP from XMP. | Translation elongation factor EF-Ts (tsf); Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome. Belongs to the EF-Ts family. | 0.771 |
| guaA | typA | AMF_897 | AMF_537 | GMP synthase (glutamine-hydrolyzing) (guaA); Catalyzes the synthesis of GMP from XMP. | GTP-binding protein TypA (typA); Psort: bacterial inner membrane --- Certainty= 0.157(Affirmative); COG1217 TypA predicted membrane GTPase involved in stress response. | 0.800 |
| gyrA | guaA | AMF_273 | AMF_897 | DNA gyrase subunit A (gyrA); A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | GMP synthase (glutamine-hydrolyzing) (guaA); Catalyzes the synthesis of GMP from XMP. | 0.553 |
| gyrA | polA | AMF_273 | AMF_914 | DNA gyrase subunit A (gyrA); A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | DNA polymerase I (polA); In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.814 |
| gyrA | rpoB | AMF_273 | AMF_194 | DNA gyrase subunit A (gyrA); A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | RNA polymerase beta subunit (rpoB); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.632 |
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