STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
acrDAcriflavin resistance protein D (acrD); Psort: bacterial inner membrane --- Certainty= 0.722(Affirmative); COG0841 AcrB cation/multidrug efflux pump; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. (1037 aa)    
Predicted Functional Partners:
hlyD
Putative secretion protein hlyD; Psort: bacterial cytoplasm --- Certainty= 0.244(Affirmative); COG0845 AcrA Membrane-fusion protein; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
 
 
 0.988
tolC
Outer membrane protein (tolC); Psort: bacterial inner membrane --- Certainty= 0.295(Affirmative); COG1538 TolC outer membrane protein.
  
 
 0.924
yajC
Preprotein translocase subunit (yajC); The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein secretase/insertase is a supercomplex required for protein secretion, insertion of proteins into membranes, and assembly of membrane protein complexes. While the SecYEG complex is essential for assembly of a number of proteins and complexes, the SecDF-YajC-YidC subcomplex facilitates these functions.
  
 
 
 0.739
dhkA
Sensory box histidine kinase/response regulator (dhkA); Psort: bacterial inner membrane --- Certainty= 0.491(Affirmative); COG0642 Signal transduction histidine kinase.
  
 
 
 0.544
tatC
Sec-independent protein translocase protein tatC (tatC); Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin- arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides.
       0.539
AMF_117
Called by Glimmer 2; Conserved hypothetical protein called by Glimmer 2; psort: bacterial inner membrane --- Certainty= 0.576(Affirmative); COG1593 Integral membrane protein, possible transporter.
  
     0.519
gcpE
Peptidoglycan acetylation protein (gcpE); Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family.
       0.446
aprE
Alkaline protease secretion protein (aprE); Psort: bacterial inner membrane --- Certainty= 0.569(Affirmative); COG1404 aprE subtilisin-like serine proteases.
     
 0.441
AMF_417
Called by Glimmer 2; Conserved hypothetical protein called by Glimmer 2; C-terminal end matches AMF_428; psort: bacterial periplasmic space --- Certainty= 0.294(Affirmative); COG2358 Predicted periplasmic binding protein.
  
     0.409
Your Current Organism:
Anaplasma marginale
NCBI taxonomy Id: 320483
Other names: A. marginale str. Florida, Anaplasma marginale str. Florida, Anaplasma marginale strain Florida
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.