Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
hemFCoproporphyrinogen III oxidase (hemF); Psort: bacterial cytoplasm --- Certainty= 0.612(Affirmative); COG0408 HemF coproporphyrinogen III oxidase. (292 aa)    
Predicted Functional Partners:
hemE
Uroporphyrinogen decarboxylase (hemE); Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
 
 0.970
AMF_1024
Called by Glimmer 2; Conserved hypothetical protein called by Glimmer 2; psort: bacterial inner membrane --- Certainty= 0.401(Affirmative); COG1981 Predicted membrane protein.
 
  
 0.943
hemC
Porphobilinogen deaminase (hemC); Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
  
 
 0.651
hemB
Delta-aminolevulinic acid dehydratase (hemB); Psort: bacterial inner membrane --- Certainty= 0.202(Affirmative); COG0113 HemB delta-aminolevulinic acid dehydratase; Belongs to the ALAD family.
  
 
 0.645
hemH
Ferrochelatase (hemH); Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family.
 
  
 0.642
ubiD
3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Psort: bacterial inner membrane --- Certainty= 0.106(Affirmative); COG0043 UbiD 3-polyprenyl-4-hydroxybenzoate decarboxylase and related decarboxylases; Belongs to the UbiD family.
    
 
 0.560
hemD
HemD; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III.
     
 0.551
ctaB
Cytochrome c oxidase assembly factor (ctaB); Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.
      
 0.516
tdpX1
Thioredoxin peroxidase 1 (tdpX1); Psort: bacterial cytoplasm --- Certainty= 0.065(Affirmative); COG0450 AhpC peroxiredoxin.
  
 
 0.477
agk
Acetylglutamate kinase (agk); Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate.
       0.463
Your Current Organism:
Anaplasma marginale
NCBI taxonomy Id: 320483
Other names: A. marginale str. Florida, Anaplasma marginale str. Florida, Anaplasma marginale strain Florida
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