STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
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[Homology]
Score
murFUDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate-D-alanyl-D-alanyl ligase (murF); Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. (476 aa)    
Predicted Functional Partners:
murE
UDP-N-acetylmuramoylalanyl-D-glutamate-- 2,6-diaminopimelate ligase (murE); Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily.
 
0.999
mraY1
Phospho-n-acetylmuramoyl-pentapeptide- transferase (mraY1); First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily.
 
 0.997
ddlB
D-alanine--D-alanine ligase (ddlB); Cell wall formation.
 
 0.995
murD
UDP-N-acetylmuramoylalanine--D-glutamate ligase (murD); Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family.
 
  
 0.987
murG
Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily.
 
  
 0.981
murC
UDP-N-acetylmuramate-alanine ligase (murC); Cell wall formation; Belongs to the MurCDEF family.
 
  
 0.978
ftsW
Cell division protein ftsW (ftsW); Psort: bacterial inner membrane --- Certainty= 0.595(Affirmative); COG0772 FtsW bacterial cell division membrane protein; Belongs to the SEDS family.
 
 
 0.935
murA
UDP-N-acetylglucosamine 1-carboxyvinyltransferase (murA); Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily.
 
   
 0.871
murB
UDP-N-acetylenolpyruvoylglucosamine reductase (murB); Cell wall formation.
 
  
 0.864
pbpA2
Penicillin-binding protein (pbpA2); Psort: bacterial inner membrane --- Certainty= 0.516(Affirmative); COG0768 FtsI cell division protein FtsI/penicillin-binding protein 2.
 
  
 0.845
Your Current Organism:
Anaplasma marginale
NCBI taxonomy Id: 320483
Other names: A. marginale str. Florida, Anaplasma marginale str. Florida, Anaplasma marginale strain Florida
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