STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hemDHemD; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (237 aa)    
Predicted Functional Partners:
hemC
Porphobilinogen deaminase (hemC); Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family.
  
 0.995
hemE
Uroporphyrinogen decarboxylase (hemE); Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
  
 
 0.968
hemB
Delta-aminolevulinic acid dehydratase (hemB); Psort: bacterial inner membrane --- Certainty= 0.202(Affirmative); COG0113 HemB delta-aminolevulinic acid dehydratase; Belongs to the ALAD family.
  
 
 0.937
hemH
Ferrochelatase (hemH); Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family.
  
  
 0.725
hemF
Coproporphyrinogen III oxidase (hemF); Psort: bacterial cytoplasm --- Certainty= 0.612(Affirmative); COG0408 HemF coproporphyrinogen III oxidase.
     
 0.707
holA
Putative DNA polymerase III delta subunit (holA); Psort: bacterial cytoplasm --- Certainty= 0.398(Affirmative); COG1466 HolA DNA polymerase III delta subunit.
 
     0.691
AMF_245
Called by Glimmer 2; Conserved hypothetical protein called by Glimmer 2; psort: bacterial periplasmic space --- Certainty= 0.919(Affirmative).
 
     0.685
AMF_308
Called by Glimmer 2; Conserved hypothetical protein called by Glimmer 2; psort: bacterial inner membrane --- Certainty= 0.274(Affirmative).
  
     0.660
ccmC
Cytochrome c-type biogenesis protein (ccmC); Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes; Belongs to the CcmC/CycZ/HelC family.
  
    0.609
AMF_238
Called by Glimmer 2; Conserved hypothetical protein called by Glimmer 2; psort: bacterial inner membrane --- Certainty= 0.196(Affirmative); COG0762 Predicted integral membrane protein.
 
     0.590
Your Current Organism:
Anaplasma marginale
NCBI taxonomy Id: 320483
Other names: A. marginale str. Florida, Anaplasma marginale str. Florida, Anaplasma marginale strain Florida
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