Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
AMF_624Called by Glimmer 2; Conserved hypothetical protein called by Glimmer 2; psort: bacterial inner membrane --- Certainty= 0.037(Affirmative); COG3298 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB. (286 aa)    
Predicted Functional Partners:
dnaN
DNA polymerase III beta chain (dnaN); Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiatio [...]
  
 0.970
polA
DNA polymerase I (polA); In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
   
 0.968
recA
recA protein (recA); Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
  
 0.843
era
GTP-binding protein ERA (era); An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
       0.827
htpG
Heat shock protein (htpG); Molecular chaperone. Has ATPase activity.
    
   0.723
rnhB
Ribonuclease HII (rnhB); Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.
   
 
 0.677
xthA2
Exodeoxyribonuclease III (xthA2); Psort: bacterial cytoplasm --- Certainty= 0.293(Affirmative); COG0708 XthA exonuclease III.
  
 0.673
mutS
DNA mismatch repair protein (mutS); This protein is involved in the repair of mismatches in DNA.
   
 
 0.634
AMF_403
Hypothetical protein called by Glimmer 2; Significant similarity to AMF_405, AMF_406, AMF_407, AMF_408 psort: bacterial inner membrane --- Certainty= 0.452(Affirmative).
   
 0.608
AMF_405
Hypothetical protein called by Glimmer 2; Significant similarity to AMF_403, AMF_406, AMF_407, AMF_404 psort: bacterial periplasmic space --- Certainty= 0.950(Affirmative).
   
 0.608
Your Current Organism:
Anaplasma marginale
NCBI taxonomy Id: 320483
Other names: A. marginale str. Florida, Anaplasma marginale str. Florida, Anaplasma marginale strain Florida
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