Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
dnaBReplicative DNA helicase (dnaB); Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. (492 aa)    
Predicted Functional Partners:
dnaG
DNA primase (dnaG); RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication.
 0.958
dnaA
Chromosomal replication initiator protein (dnaA); Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family.
  
 
 0.928
AMF_220
Called by Glimmer 2; Conserved hypothetical protein called by Glimmer 2; psort: bacterial cytoplasm --- Certainty= 0.237(Affirmative); COG0593 ATPase involved in DNA replication initiation; Belongs to the DnaA family.
  
 
 
 0.771
dnaX
DNA polymerase III subunit gamma; Psort: bacterial cytoplasm --- Certainty= 0.235(Affirmative); COG2812 DnaX DNA polymerase III, gamma/tau subunits.
 
 
 0.684
uvrD
DNA helicase II (uvrD); Psort: bacterial inner membrane --- Certainty= 0.132(Affirmative); COG0210 UvrD superfamily I DNA and RNA helicases.
   
 
 0.681
ssb
Single-strand binding protein (ssb); Psort: bacterial cytoplasm --- Certainty= 0.082(Affirmative); COG0629 Ssb single-stranded DNA-binding protein.
  
 
 0.657
polA
DNA polymerase I (polA); In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
  
 0.654
dnaE
DNA polymerase III, alpha subunit (dnaE); Psort: bacterial inner membrane --- Certainty= 0.113(Affirmative); COG0587 DnaE DNA polymerase III alpha subunit.
 
 
 0.637
AMF_649
Called by Glimmer 2; Conserved hypothetical protein called by Glimmer 2; psort: bacterial inner membrane --- Certainty= 0.236(Affirmative).
       0.618
dnaZ
DNA polymerase III gamma subunit (dnaZ); DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.
  
 
 0.592
Your Current Organism:
Anaplasma marginale
NCBI taxonomy Id: 320483
Other names: A. marginale str. Florida, Anaplasma marginale str. Florida, Anaplasma marginale strain Florida
Server load: low (12%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.