STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
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Coexpression
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[Homology]
Score
folPDihydropteroate synthase (folP); Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (291 aa)    
Predicted Functional Partners:
folP-2
2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase (folP/K); Psort: bacterial cytoplasm --- Certainty= 0.253(Affirmative); COG0294 FolP Dihydropteroate synthase and related enzymes.
 
 0.999
folC
Folylpolyglutamate synthase (folC); Psort: bacterial inner membrane --- Certainty= 0.095(Affirmative); COG0285 FolC folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family.
 
 0.997
folB
Dihydroneopterin aldolase (folB); Psort: bacterial inner membrane --- Certainty= 0.033(Affirmative); COG1539 FolB dihydroneopterin aldolase.
  
 
 0.994
folE
GTP cyclohydrolase I (folE); Psort: bacterial inner membrane --- Certainty= 0.174(Affirmative); COG0302 FolE GTP cyclohydrolase I; Belongs to the GTP cyclohydrolase I family.
 
  
 0.962
ribH
Riboflavin synthase, beta subunit; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.
   
  
 0.659
guaB
Inosine monophosphate dehydrogenase (guaB); Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
  
  
 0.639
ribD
Riboflavin biosynthesis protein (ribD); Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family.
     
 0.615
glmM
Phosphoglucosamine mutase (glmM/femD); Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family.
  
  
 0.609
hscA
Heat shock protein (hscA); Chaperone involved in the maturation of iron-sulfur cluster- containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB.
   
    0.565
dnaK
DNAK protein; Acts as a chaperone; Belongs to the heat shock protein 70 family.
   
    0.565
Your Current Organism:
Anaplasma marginale
NCBI taxonomy Id: 320483
Other names: A. marginale str. Florida, Anaplasma marginale str. Florida, Anaplasma marginale strain Florida
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