STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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Textmining
[Homology]
Score
purNPhosphoribosylglycinamide formyl transferase (purN); Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (214 aa)    
Predicted Functional Partners:
purD
Phosphoribosylamine-glycine ligase (purD); Psort: bacterial cytoplasm --- Certainty= 0.188(Affirmative); COG0151 PurD phosphoribosylamine-glycine ligase; Belongs to the GARS family.
 
 0.999
purH
Phosphoribosylaminoimidazolecarboxamide formyltransferase (AICAR transformylase)(purH); Psort: bacterial inner membrane --- Certainty= 0.162(Affirmative); COG0138 PurH AICAR transformylase/IMP cyclohydrolase PurH.
 0.999
purM
Phosphoribosylaminoimidazole synthetase (AIR synthetase) (purM); Psort: bacterial cytoplasm --- Certainty= 0.099(Affirmative); COG0150 PurM phosphoribosylaminoimidazol (AIR) synthetase.
  
 0.998
purQ
Phosphoribosylformylglycinamidine synthase I (purQ); Psort: bacterial inner membrane --- Certainty= 0.177(Affirmative); COG0046 PurL phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain.
  
 
 0.997
purL
Phosphoribosylformylglycinamidine synthase (PurL); Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to ass [...]
  
 
 0.997
purC
Phosphoribosoylaminoimidazole-succinocarboxamide synthase (purC); Psort: bacterial cytoplasm --- Certainty= 0.378(Affirmative); COG0152 PurC phosphoribosylaminoimidazole-succinocarboxamide (SAICAR) synthase; Belongs to the SAICAR synthetase family.
  
 
 0.987
purF
Amidophosphoribosyltransferase (purF); Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
  
 
 0.982
purE
Phosphoribosylaminoimidazole carboxylase catalytic subunit (purE); Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).
  
  
 0.980
purK
Phosphoribosylaminoimidazole carboxylase (purK); Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
  
  
 0.980
glyA
Glycine/serine hydroxymethyltransferase (glyA); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 0.975
Your Current Organism:
Anaplasma marginale
NCBI taxonomy Id: 320483
Other names: A. marginale str. Florida, Anaplasma marginale str. Florida, Anaplasma marginale strain Florida
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