STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
folP-22-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase (folP/K); Psort: bacterial cytoplasm --- Certainty= 0.253(Affirmative); COG0294 FolP Dihydropteroate synthase and related enzymes. (234 aa)    
Predicted Functional Partners:
folP
Dihydropteroate synthase (folP); Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives.
 
 0.999
folB
Dihydroneopterin aldolase (folB); Psort: bacterial inner membrane --- Certainty= 0.033(Affirmative); COG1539 FolB dihydroneopterin aldolase.
  
 
 0.997
folE
GTP cyclohydrolase I (folE); Psort: bacterial inner membrane --- Certainty= 0.174(Affirmative); COG0302 FolE GTP cyclohydrolase I; Belongs to the GTP cyclohydrolase I family.
 
  
 0.986
ribD
Riboflavin biosynthesis protein (ribD); Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family.
  
  
 0.666
folC
Folylpolyglutamate synthase (folC); Psort: bacterial inner membrane --- Certainty= 0.095(Affirmative); COG0285 FolC folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family.
  
  
 0.626
nnrD
Conserved hypothetical protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair o [...]
     
 0.540
pcnB
Poly (A) polymerase (pcnB); Psort: bacterial cytoplasm --- Certainty= 0.092(Affirmative; COG0617 PcnB tRNA nucleotidyltransferase/poly(A) polymerase.
  
    0.437
hisS
Histidyl tRNA synthetase (hisS); Psort: bacterial cytoplasm --- Certainty= 0.492(Affirmative); COG0124 hisS histidyl-tRNA synthetase.
     
 0.406
Your Current Organism:
Anaplasma marginale
NCBI taxonomy Id: 320483
Other names: A. marginale str. Florida, Anaplasma marginale str. Florida, Anaplasma marginale strain Florida
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