STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
sucBDihydrolipoamide acetyltransferase component (sucB); Psort: bacterial inner membrane --- Certainty= 0.238(Affirmative); COG0508 AceF dihydrolipoamide acyltransferases. (437 aa)    
Predicted Functional Partners:
sucA
2-oxoglutarate dehydrogenase E1 component (sucA); Psort: bacterial cytoplasm --- Certainty= 0.276(Affirmative); COG0567 SucA pyruvate and 2-oxoglutarate dehydrogenases, E1 component.
 0.999
pdhD
Dihydrolipoamide dehydrogenase (pdhD); Psort: bacterial inner membrane --- Certainty= 0.117(Affirmative).
 0.997
lpdA
Dihydrolipoamide dehydrogenase (lpdA); Psort: bacterial membrane --- Certainty= 0.512(Affirmative); COG1249 Lpd dihydrolipoamide dehydrogenase/glutathione oxidoreductase and related enzymes.
 0.997
pdhB
Pyruvate dehydrogenase E1 beta subunit precursor (pdhB); The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.
 
 0.996
sucD
succinyl-CoA ligase chain A (sucD); Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
  
 0.986
sucC
succinyl-CoA synthetase beta chain (sucC); Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
  
 0.985
pdhA
Pyruvate dehydrogenase E1 component, alpha subunit precursor (pdhA); The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
 
 0.981
prsA
Ribose-phosphate pyrophosphokinase (prsA); Psort: bacterial periplasmic space --- Certainty= 0.933(Affirmative); COG0462 PrsA phosphoribosylpyrophosphate synthetase.
   
 0.919
dhkA
Sensory box histidine kinase/response regulator (dhkA); Psort: bacterial inner membrane --- Certainty= 0.491(Affirmative); COG0642 Signal transduction histidine kinase.
    
 0.804
map
Methionine aminopeptidase (map); Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed; Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
  
    0.801
Your Current Organism:
Anaplasma marginale
NCBI taxonomy Id: 320483
Other names: A. marginale str. Florida, Anaplasma marginale str. Florida, Anaplasma marginale strain Florida
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