STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pgsACDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase (pgsA); Psort: bacterial inner membrane --- Certainty= 0.359(Affirmative); COG0558 PgsA phosphatidylglycerophosphate synthase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (147 aa)    
Predicted Functional Partners:
pgpA
Phosphatidylglycerophosphatase A (pgpA); Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG).
 
  
 0.963
cdsA
Phosphatidate cytidylyltransferase (cdsA); COG0575 CdsA CDP-diglyceride synthetase.
  
 
 0.956
pssA
CDP-diacylglycerol--serine O-phosphatidyltransferase (pssA); Psort: bacterial inner membrane --- Certainty= 0.469(Affirmative); COG1183 PssA phosphatidylserine synthase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family.
  
 
 0.952
psd
Phosphatidylserine decarboxylase proenzyme (psd); Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).
    
 
 0.803
folD
Methylenetetrahydrofolate dehydrogenase (folD); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.
  
  
 0.672
nnrD
Conserved hypothetical protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair o [...]
  
  
 0.624
plsC
1-acyl-sn-glycerol-3-phosphate acyltransferase (plsC); Psort: bacterial inner membrane --- Certainty= 0.385(Affirmative); COG0204 PlsC 1-acyl-sn-glycerol-3-phosphate acyltransferase.
  
 
 0.610
guaB
Inosine monophosphate dehydrogenase (guaB); Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
     
 0.605
cinA
Competence / damage-inducible protein (cinA); Psort: bacterial inner membrane --- Certainty= 0.304(Affirmative); COG1058 CinA predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA.
  
  
 0.585
uvrC
Excinuclease ABC subunit C (uvrC); The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.
     
 0.562
Your Current Organism:
Anaplasma marginale
NCBI taxonomy Id: 320483
Other names: A. marginale str. Florida, Anaplasma marginale str. Florida, Anaplasma marginale strain Florida
Server load: medium (54%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.