STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ftsHCell division protein (ftsH); Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. (610 aa)    
Predicted Functional Partners:
hflK-2
hflK protein; HflC and HflK could encode or regulate a protease.
   
 0.987
hflC
hflC protein; HflC and HflK could regulate a protease.
   
 0.985
hflK
HFLK protein (hflK); Psort: bacterial inner membrane --- Certainty= 0.397(Affirmative); COG0330 HflC membrane protease subunits, stomatin/prohibitin homologs.
   
 0.940
rplO
50S ribosomal protein L15 (rplO); Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family.
   
   0.904
rplS
50S ribosomal subunit L19 (rplS); This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.
   
   0.899
rpmA
50S ribosomal protein L27 (rpmA); Psort: bacterial cytoplasm --- Certainty= 0.450(Affirmative); COG0211 RpmA ribosomal protein L27.
  
 
 0.898
rplM
50S ribosomal protein L13 (rplM); This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.
  
 
 0.898
rplQ
50S ribosomal protein L17 (rplQ); Psort: bacterial cytoplasm --- Certainty= 0.046(Affirmative); COG0203 RplQ ribosomal protein L17.
   
 
 0.893
rplB
50S ribosomal protein L2 (rplB); One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family.
   
 
 0.890
rpsE
30S ribosomal protein S5 (rpsE); With S4 and S12 plays an important role in translational accuracy; Belongs to the universal ribosomal protein uS5 family.
   
 
 0.887
Your Current Organism:
Anaplasma marginale
NCBI taxonomy Id: 320483
Other names: A. marginale str. Florida, Anaplasma marginale str. Florida, Anaplasma marginale strain Florida
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.