STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
dtbSDethiobiotin synthase (dtbS); Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (233 aa)    
Predicted Functional Partners:
bioA
Psort: bacterial cytoplasm --- Certainty= 0.133(Affirmative); COG0161 adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
 
 
 0.998
bioB
Biotin synthase (bioB); Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family.
 
 
 0.997
bioF
8-amino-7-oxononanoate synthase; Psort: bacterial inner membrane --- Certainty= 0.132(Affirmative); COG0156 BioF 7-keto-8-aminopelargonate synthetase and related enzymes.
 
  
 0.949
hemA
5-c acid synthase (delta-aminolevulinate synthase) (hemA); Psort: bacterial inner membrane --- Certainty= 0.104(Affirmative); COG0113 HemB delta-aminolevulinic acid dehydratase.
 
  
 0.843
ftsY
Cell division protein (ftsY); Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC). Interaction with SRP-RNC leads to the transfer of the RNC complex to the Sec translocase for insertion into the membrane, the hydrolysis of GTP by both Ffh and FtsY, and the dissociation of the SRP-FtsY complex into the individual components.
     
 0.595
AMF_072
Called by Glimmer 2; Conserved hypothetical protein called by Glimmer 2; psort: bacterial inner membrane --- Certainty= 0.121(Affirmative); COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily).
  
  
 0.504
birA
biotin-(acetyl-CoA carboxylase) (birA); Psort: bacterial inner membrane --- Certainty= 0.145(Affirmative); COG0340 BirA biotin-(acetyl-CoA carboxylase) ligase.
  
  
 0.504
ribD
Riboflavin biosynthesis protein (ribD); Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family.
     
 0.485
nadC
Nicotinate-nucleotide pyrophosphorylase (nadC); Psort: bacterial cytoplasm --- Certainty= 0.379(Affirmative); COG0157 NadC nicotinate-nucleotide pyrophosphorylase; Belongs to the NadC/ModD family.
  
  
 0.484
thiG
Thiazole biosynthesis protein (thiG); Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.
  
  
 0.469
Your Current Organism:
Anaplasma marginale
NCBI taxonomy Id: 320483
Other names: A. marginale str. Florida, Anaplasma marginale str. Florida, Anaplasma marginale strain Florida
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