Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
gltACitrate synthase (gltA); Psort: bacterial cytoplasm --- Certainty= 0.043(Affirmative); COG0372 GltA citrate synthase. (427 aa)    
Predicted Functional Partners:
mdh
Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family.
  
 0.998
acnA
Aconitate hydratase (acnA); Catalyzes the isomerization of citrate to isocitrate via cis- aconitate.
  
 0.998
fumC
Fumarate hydratase (fumC); Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
   
 0.988
pdhC
Dihydrolipoamide acetyltransferase component (pdhC); The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
  
 0.985
sucC
succinyl-CoA synthetase beta chain (sucC); Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
  
 0.967
sucA
2-oxoglutarate dehydrogenase E1 component (sucA); Psort: bacterial cytoplasm --- Certainty= 0.276(Affirmative); COG0567 SucA pyruvate and 2-oxoglutarate dehydrogenases, E1 component.
  
 0.960
maeB
Malate dehydrogenase and phosphate acetyltransferase (maeB); Psort: bacterial inner membrane --- Certainty= 0.140(Affirmative); COG0039 Mdh malate/lactate dehydrogenases.
  
 
 0.955
sdhB
Succinate dehydrogenase iron-sulfur protein (sdhB/frdB); Psort: bacterial cytoplasm --- Certainty= 0.392(Affirmative); COG0479 FrdB succinate dehydrogenase/fumarate reductase Fe-S protein.
  
 
 0.942
icd
Isocitrate dehydrogenase (icd); Psort: bacterial cytoplasm --- Certainty= 0.104(Affirmative); COG0538 Icd isocitrate dehydrogenases.
  
 0.939
atpA
F1-ATP synthase alpha subunit (atpA); Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. Belongs to the ATPase alpha/beta chains family.
   
 0.922
Your Current Organism:
Anaplasma marginale
NCBI taxonomy Id: 320483
Other names: A. marginale str. Florida, Anaplasma marginale str. Florida, Anaplasma marginale strain Florida
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