| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| gshA | secE | AMF_895 | AMF_187 | Glutamate-cysteine ligase (gshA); Psort: bacterial cytoplasm --- Certainty= 0.336(Affirmative); COG2918 GshA Gamma-glutamylcysteine synthetase. | Conserved family - SecE subunit; Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation. | 0.620 |
| gshA | secF | AMF_895 | AMF_903 | Glutamate-cysteine ligase (gshA); Psort: bacterial cytoplasm --- Certainty= 0.336(Affirmative); COG2918 GshA Gamma-glutamylcysteine synthetase. | Protein export membrane protein secF (secF); Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. | 0.900 |
| gshA | secY | AMF_895 | AMF_677 | Glutamate-cysteine ligase (gshA); Psort: bacterial cytoplasm --- Certainty= 0.336(Affirmative); COG2918 GshA Gamma-glutamylcysteine synthetase. | Preprotein translocase secY subunit (secY); The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. | 0.637 |
| gshA | yajC | AMF_895 | AMF_771 | Glutamate-cysteine ligase (gshA); Psort: bacterial cytoplasm --- Certainty= 0.336(Affirmative); COG2918 GshA Gamma-glutamylcysteine synthetase. | Preprotein translocase subunit (yajC); The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein secretase/insertase is a supercomplex required for protein secretion, insertion of proteins into membranes, and assembly of membrane protein complexes. While the SecYEG complex is essential for assembly of a number of proteins and complexes, the SecDF-YajC-YidC subcomplex facilitates these functions. | 0.410 |
| gshA | yidC | AMF_895 | AMF_339 | Glutamate-cysteine ligase (gshA); Psort: bacterial cytoplasm --- Certainty= 0.336(Affirmative); COG2918 GshA Gamma-glutamylcysteine synthetase. | 60kD inner-membrane protein (yidC); Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins. | 0.685 |
| lepB | secD | AMF_528 | AMF_942 | Signal peptidase I (lepB); Psort: bacterial inner membrane --- Certainty= 0.147(Affirmative); COG0681 LepB signal peptidase I; Belongs to the peptidase S26 family. | Protein-export membrane protein (secD); Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. | 0.668 |
| lepB | secE | AMF_528 | AMF_187 | Signal peptidase I (lepB); Psort: bacterial inner membrane --- Certainty= 0.147(Affirmative); COG0681 LepB signal peptidase I; Belongs to the peptidase S26 family. | Conserved family - SecE subunit; Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation. | 0.467 |
| lepB | secF | AMF_528 | AMF_903 | Signal peptidase I (lepB); Psort: bacterial inner membrane --- Certainty= 0.147(Affirmative); COG0681 LepB signal peptidase I; Belongs to the peptidase S26 family. | Protein export membrane protein secF (secF); Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. | 0.612 |
| lepB | secY | AMF_528 | AMF_677 | Signal peptidase I (lepB); Psort: bacterial inner membrane --- Certainty= 0.147(Affirmative); COG0681 LepB signal peptidase I; Belongs to the peptidase S26 family. | Preprotein translocase secY subunit (secY); The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. | 0.592 |
| lepB | yajC | AMF_528 | AMF_771 | Signal peptidase I (lepB); Psort: bacterial inner membrane --- Certainty= 0.147(Affirmative); COG0681 LepB signal peptidase I; Belongs to the peptidase S26 family. | Preprotein translocase subunit (yajC); The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein secretase/insertase is a supercomplex required for protein secretion, insertion of proteins into membranes, and assembly of membrane protein complexes. While the SecYEG complex is essential for assembly of a number of proteins and complexes, the SecDF-YajC-YidC subcomplex facilitates these functions. | 0.492 |
| lepB | yidC | AMF_528 | AMF_339 | Signal peptidase I (lepB); Psort: bacterial inner membrane --- Certainty= 0.147(Affirmative); COG0681 LepB signal peptidase I; Belongs to the peptidase S26 family. | 60kD inner-membrane protein (yidC); Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins. | 0.686 |
| lgt | secF | AMF_930 | AMF_903 | Prolipoprotein diacylglyceryl transferase (lgt); Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins; Belongs to the Lgt family. | Protein export membrane protein secF (secF); Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. | 0.595 |
| lgt | yidC | AMF_930 | AMF_339 | Prolipoprotein diacylglyceryl transferase (lgt); Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins; Belongs to the Lgt family. | 60kD inner-membrane protein (yidC); Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins. | 0.733 |
| pbpA1 | secF | AMF_902 | AMF_903 | Penicillin-binding protein (pbpA1); Psort: bacterial inner membrane --- Certainty= 0.348(Affirmative); COG0768 FtsI cell division protein FtsI/penicillin-binding protein 2. | Protein export membrane protein secF (secF); Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. | 0.812 |
| pbpA1 | topA | AMF_902 | AMF_373 | Penicillin-binding protein (pbpA1); Psort: bacterial inner membrane --- Certainty= 0.348(Affirmative); COG0768 FtsI cell division protein FtsI/penicillin-binding protein 2. | DNA topoisomerase I (topA); Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing D [...] | 0.455 |
| secD | lepB | AMF_942 | AMF_528 | Protein-export membrane protein (secD); Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. | Signal peptidase I (lepB); Psort: bacterial inner membrane --- Certainty= 0.147(Affirmative); COG0681 LepB signal peptidase I; Belongs to the peptidase S26 family. | 0.668 |
| secD | secE | AMF_942 | AMF_187 | Protein-export membrane protein (secD); Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. | Conserved family - SecE subunit; Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation. | 0.901 |
| secD | secF | AMF_942 | AMF_903 | Protein-export membrane protein (secD); Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. | Protein export membrane protein secF (secF); Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. | 0.999 |
| secD | secY | AMF_942 | AMF_677 | Protein-export membrane protein (secD); Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. | Preprotein translocase secY subunit (secY); The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. | 0.907 |
| secD | topA | AMF_942 | AMF_373 | Protein-export membrane protein (secD); Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. | DNA topoisomerase I (topA); Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing D [...] | 0.612 |
