STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
polADNA polymerase I (polA); In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (864 aa)    
Predicted Functional Partners:
recA
recA protein (recA); Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
  
 0.999
dnaN
DNA polymerase III beta chain (dnaN); Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiatio [...]
  
 0.999
AMF_624
Called by Glimmer 2; Conserved hypothetical protein called by Glimmer 2; psort: bacterial inner membrane --- Certainty= 0.037(Affirmative); COG3298 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB.
   
 0.996
mutS
DNA mismatch repair protein (mutS); This protein is involved in the repair of mismatches in DNA.
   
 0.994
mutL
DNA mismatch repair protein (mutL); This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex.
   
 0.992
fpg
formamidopyrimidine-DNA glycosylase (fpg); Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
  
  
 0.989
AMF_403
Hypothetical protein called by Glimmer 2; Significant similarity to AMF_405, AMF_406, AMF_407, AMF_408 psort: bacterial inner membrane --- Certainty= 0.452(Affirmative).
  
 0.969
AMF_405
Hypothetical protein called by Glimmer 2; Significant similarity to AMF_403, AMF_406, AMF_407, AMF_404 psort: bacterial periplasmic space --- Certainty= 0.950(Affirmative).
  
 0.969
AMF_406
Hypothetical protein called by Glimmer 2; Significant sequence similarity with AMF_405, AMF_403, AMF_407, and AMF_404 ; psort: bacterial inner membrane --- Certainty= 0.699(Affirmative).
  
 0.969
xthA2
Exodeoxyribonuclease III (xthA2); Psort: bacterial cytoplasm --- Certainty= 0.293(Affirmative); COG0708 XthA exonuclease III.
  
 0.962
Your Current Organism:
Anaplasma marginale
NCBI taxonomy Id: 320483
Other names: A. marginale str. Florida, Anaplasma marginale str. Florida, Anaplasma marginale strain Florida
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