Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
fdxAFerredoxin II (fdxA); Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. (123 aa)    
Predicted Functional Partners:
mdh
Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family.
  
  
 0.869
AMF_342
Called by Glimmer 2; Conserved hypothetical protein called by Glimmer 2; psort: bacterial inner membrane --- Certainty= 0.302(Affirmative); COG0493 NADPH-dependent glutamate synthase beta chain and related oxidoreductases.
 
 
 0.814
ilvC
Ketol-acid reductoisomerase (ilvC); Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
     
 0.560
maeB
Malate dehydrogenase and phosphate acetyltransferase (maeB); Psort: bacterial inner membrane --- Certainty= 0.140(Affirmative); COG0039 Mdh malate/lactate dehydrogenases.
     
 0.513
sdhA
Succinate dehydrogenase flavoprotein subunit (sdhA/frdA); Psort: bacterial inner membrane --- Certainty= 0.202(Affirmative); COG1053 SdhA succinate dehydrogenase/fumarate reductase, flavoprotein subunits; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.
  
  
 0.513
Your Current Organism:
Anaplasma marginale
NCBI taxonomy Id: 320483
Other names: A. marginale str. Florida, Anaplasma marginale str. Florida, Anaplasma marginale strain Florida
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