node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CUH52700.1 | clpA | SHM7688_02147 | SHM7688_01799 | Hypothetical protein. | ATP-dependent Clp protease ATP-binding subunit ClpA; Belongs to the ClpA/ClpB family. | 0.802 |
CUH52700.1 | clpB | SHM7688_02147 | SHM7688_02107 | Hypothetical protein. | Chaperone protein ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | 0.802 |
CUH52700.1 | dnaJ | SHM7688_02147 | SHM7688_01000 | Hypothetical protein. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.983 |
CUH52700.1 | dnaK_1 | SHM7688_02147 | SHM7688_01001 | Hypothetical protein. | Heat shock protein 70; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.996 |
CUH52700.1 | dnaK_2 | SHM7688_02147 | SHM7688_02587 | Hypothetical protein. | Heat shock protein 70. | 0.996 |
CUH52700.1 | grpE | SHM7688_02147 | SHM7688_00916 | Hypothetical protein. | HSP-70 cofactor; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependen [...] | 0.878 |
CUH52700.1 | hslU | SHM7688_02147 | SHM7688_00893 | Hypothetical protein. | Unfoldase HslU; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. | 0.880 |
CUH52700.1 | hslV | SHM7688_02147 | SHM7688_00891 | Hypothetical protein. | ATP-dependent protease subunit HslV; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. | 0.884 |
CUH52700.1 | ibpA_2 | SHM7688_02147 | SHM7688_00646 | Hypothetical protein. | 16 kDa heat shock protein A; Belongs to the small heat shock protein (HSP20) family. | 0.658 |
clpA | CUH52700.1 | SHM7688_01799 | SHM7688_02147 | ATP-dependent Clp protease ATP-binding subunit ClpA; Belongs to the ClpA/ClpB family. | Hypothetical protein. | 0.802 |
clpA | dnaJ | SHM7688_01799 | SHM7688_01000 | ATP-dependent Clp protease ATP-binding subunit ClpA; Belongs to the ClpA/ClpB family. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.757 |
clpA | dnaK_1 | SHM7688_01799 | SHM7688_01001 | ATP-dependent Clp protease ATP-binding subunit ClpA; Belongs to the ClpA/ClpB family. | Heat shock protein 70; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.982 |
clpA | dnaK_2 | SHM7688_01799 | SHM7688_02587 | ATP-dependent Clp protease ATP-binding subunit ClpA; Belongs to the ClpA/ClpB family. | Heat shock protein 70. | 0.980 |
clpA | grpE | SHM7688_01799 | SHM7688_00916 | ATP-dependent Clp protease ATP-binding subunit ClpA; Belongs to the ClpA/ClpB family. | HSP-70 cofactor; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependen [...] | 0.869 |
clpA | hslU | SHM7688_01799 | SHM7688_00893 | ATP-dependent Clp protease ATP-binding subunit ClpA; Belongs to the ClpA/ClpB family. | Unfoldase HslU; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. | 0.745 |
clpA | hslV | SHM7688_01799 | SHM7688_00891 | ATP-dependent Clp protease ATP-binding subunit ClpA; Belongs to the ClpA/ClpB family. | ATP-dependent protease subunit HslV; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. | 0.675 |
clpA | ibpA_2 | SHM7688_01799 | SHM7688_00646 | ATP-dependent Clp protease ATP-binding subunit ClpA; Belongs to the ClpA/ClpB family. | 16 kDa heat shock protein A; Belongs to the small heat shock protein (HSP20) family. | 0.823 |
clpB | CUH52700.1 | SHM7688_02107 | SHM7688_02147 | Chaperone protein ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | Hypothetical protein. | 0.802 |
clpB | dnaJ | SHM7688_02107 | SHM7688_01000 | Chaperone protein ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.814 |
clpB | dnaK_1 | SHM7688_02107 | SHM7688_01001 | Chaperone protein ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | Heat shock protein 70; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.991 |