STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
glnDPII uridylyl-transferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen metabolism. (936 aa)    
Predicted Functional Partners:
glnB_2
Nitrogen regulatory protein P-II; Belongs to the P(II) protein family.
 
 
 0.923
glnB_1
Nitrogen regulatory protein P-II; Belongs to the P(II) protein family.
 
 
 0.918
murJ
Putative peptidoglycan biosynthesis protein MurJ; Involved in peptidoglycan biosynthesis. Transports lipid- linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane.
 
   
 0.894
CUH54327.1
Putative lipoprotein.
       0.854
glnE
Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...]
 
   
 0.826
gltA_1
Glutamate synthase [NADPH] large chain.
     
 0.759
gltB
Glutamate synthase [NADPH] large chain precursor.
     
 0.759
rsmI
Ribosomal RNA small subunit methyltransferase I; Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.
       0.718
CUH54329.1
Hypothetical protein; Belongs to the UPF0102 family.
       0.676
glnL
Nitrogen regulation protein NR(II).
  
 
 
 0.665
Your Current Organism:
Shimia marina
NCBI taxonomy Id: 321267
Other names: CECT 7688, DSM 26895, JCM 13038, KCCM 42117, Rhodobacteraceae bacterium CL-TA03, S. marina, Shimia marina Choi and Cho 2006, strain CL-TA03
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