| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CYA_2455 | menA | CYA_2455 | CYA_2456 | Isochorismate synthase; Identified by match to protein family HMM PF00425; match to protein family HMM TIGR00543. | 1,4-dihydroxy-2-naphthoate phytyltransferase; Involved in the synthesis of phylloquinone (vitamin K1). Catalyzes the transfer of a prenyl chain to 2-carboxy-1,4- naphthoquinone; Belongs to the MenA family. Type 2 subfamily. | 0.829 |
| CYA_2455 | menB | CYA_2455 | CYA_0530 | Isochorismate synthase; Identified by match to protein family HMM PF00425; match to protein family HMM TIGR00543. | Naphthoate synthase; Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2- naphthoyl-CoA (DHNA-CoA). | 0.723 |
| CYA_2455 | menC | CYA_2455 | CYA_1249 | Isochorismate synthase; Identified by match to protein family HMM PF00425; match to protein family HMM TIGR00543. | O-succinylbenzoate synthetase; Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB). | 0.619 |
| CYA_2455 | menD | CYA_2455 | CYA_0082 | Isochorismate synthase; Identified by match to protein family HMM PF00425; match to protein family HMM TIGR00543. | 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylic acid synthase/2-oxoglutarate decarboxylase; Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2- succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC). | 0.995 |
| CYA_2455 | menE | CYA_2455 | CYA_2666 | Isochorismate synthase; Identified by match to protein family HMM PF00425; match to protein family HMM TIGR00543. | O-succinylbenzoate--CoA ligase; Identified by match to protein family HMM PF00501; match to protein family HMM TIGR01923. | 0.646 |
| cobA/hemD | grxC | CYA_0529 | CYA_0532 | uroporphyrin-III C-methyltransferase/uroporphyrinogen-III synthase; Identified by match to protein family HMM PF00590; match to protein family HMM PF02602; match to protein family HMM TIGR01469; Belongs to the precorrin methyltransferase family. | Glutaredoxin 3; Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins. | 0.524 |
| cobA/hemD | menB | CYA_0529 | CYA_0530 | uroporphyrin-III C-methyltransferase/uroporphyrinogen-III synthase; Identified by match to protein family HMM PF00590; match to protein family HMM PF02602; match to protein family HMM TIGR01469; Belongs to the precorrin methyltransferase family. | Naphthoate synthase; Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2- naphthoyl-CoA (DHNA-CoA). | 0.679 |
| cobA/hemD | polA | CYA_0529 | CYA_0531 | uroporphyrin-III C-methyltransferase/uroporphyrinogen-III synthase; Identified by match to protein family HMM PF00590; match to protein family HMM PF02602; match to protein family HMM TIGR01469; Belongs to the precorrin methyltransferase family. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.617 |
| cobA/hemD | ribD | CYA_0529 | CYA_0386 | uroporphyrin-III C-methyltransferase/uroporphyrinogen-III synthase; Identified by match to protein family HMM PF00590; match to protein family HMM PF02602; match to protein family HMM TIGR01469; Belongs to the precorrin methyltransferase family. | Riboflavin biosynthesis protein RibD; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. | 0.605 |
| grxC | cobA/hemD | CYA_0532 | CYA_0529 | Glutaredoxin 3; Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins. | uroporphyrin-III C-methyltransferase/uroporphyrinogen-III synthase; Identified by match to protein family HMM PF00590; match to protein family HMM PF02602; match to protein family HMM TIGR01469; Belongs to the precorrin methyltransferase family. | 0.524 |
| grxC | menB | CYA_0532 | CYA_0530 | Glutaredoxin 3; Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins. | Naphthoate synthase; Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2- naphthoyl-CoA (DHNA-CoA). | 0.478 |
| grxC | polA | CYA_0532 | CYA_0531 | Glutaredoxin 3; Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.621 |
| menA | CYA_2455 | CYA_2456 | CYA_2455 | 1,4-dihydroxy-2-naphthoate phytyltransferase; Involved in the synthesis of phylloquinone (vitamin K1). Catalyzes the transfer of a prenyl chain to 2-carboxy-1,4- naphthoquinone; Belongs to the MenA family. Type 2 subfamily. | Isochorismate synthase; Identified by match to protein family HMM PF00425; match to protein family HMM TIGR00543. | 0.829 |
| menA | menB | CYA_2456 | CYA_0530 | 1,4-dihydroxy-2-naphthoate phytyltransferase; Involved in the synthesis of phylloquinone (vitamin K1). Catalyzes the transfer of a prenyl chain to 2-carboxy-1,4- naphthoquinone; Belongs to the MenA family. Type 2 subfamily. | Naphthoate synthase; Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2- naphthoyl-CoA (DHNA-CoA). | 0.702 |
| menA | menC | CYA_2456 | CYA_1249 | 1,4-dihydroxy-2-naphthoate phytyltransferase; Involved in the synthesis of phylloquinone (vitamin K1). Catalyzes the transfer of a prenyl chain to 2-carboxy-1,4- naphthoquinone; Belongs to the MenA family. Type 2 subfamily. | O-succinylbenzoate synthetase; Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB). | 0.677 |
| menA | menD | CYA_2456 | CYA_0082 | 1,4-dihydroxy-2-naphthoate phytyltransferase; Involved in the synthesis of phylloquinone (vitamin K1). Catalyzes the transfer of a prenyl chain to 2-carboxy-1,4- naphthoquinone; Belongs to the MenA family. Type 2 subfamily. | 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylic acid synthase/2-oxoglutarate decarboxylase; Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2- succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC). | 0.813 |
| menA | menE | CYA_2456 | CYA_2666 | 1,4-dihydroxy-2-naphthoate phytyltransferase; Involved in the synthesis of phylloquinone (vitamin K1). Catalyzes the transfer of a prenyl chain to 2-carboxy-1,4- naphthoquinone; Belongs to the MenA family. Type 2 subfamily. | O-succinylbenzoate--CoA ligase; Identified by match to protein family HMM PF00501; match to protein family HMM TIGR01923. | 0.425 |
| menB | CYA_2455 | CYA_0530 | CYA_2455 | Naphthoate synthase; Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2- naphthoyl-CoA (DHNA-CoA). | Isochorismate synthase; Identified by match to protein family HMM PF00425; match to protein family HMM TIGR00543. | 0.723 |
| menB | cobA/hemD | CYA_0530 | CYA_0529 | Naphthoate synthase; Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2- naphthoyl-CoA (DHNA-CoA). | uroporphyrin-III C-methyltransferase/uroporphyrinogen-III synthase; Identified by match to protein family HMM PF00590; match to protein family HMM PF02602; match to protein family HMM TIGR01469; Belongs to the precorrin methyltransferase family. | 0.679 |
| menB | grxC | CYA_0530 | CYA_0532 | Naphthoate synthase; Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2- naphthoyl-CoA (DHNA-CoA). | Glutaredoxin 3; Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins. | 0.478 |