| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CYA_1304 | CYA_2579 | CYA_1304 | CYA_2579 | Identified by match to protein family HMM PF02219; Belongs to the methylenetetrahydrofolate reductase family. | Iron-sulfur cluster-binding protein; Identified by match to protein family HMM PF00037. | 0.852 |
| CYA_1304 | folD | CYA_1304 | CYA_1974 | Identified by match to protein family HMM PF02219; Belongs to the methylenetetrahydrofolate reductase family. | FolD bifunctional protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.934 |
| CYA_1304 | gcvH | CYA_1304 | CYA_0482 | Identified by match to protein family HMM PF02219; Belongs to the methylenetetrahydrofolate reductase family. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.934 |
| CYA_1304 | gcvP | CYA_1304 | CYA_2098 | Identified by match to protein family HMM PF02219; Belongs to the methylenetetrahydrofolate reductase family. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.966 |
| CYA_1304 | gcvT | CYA_1304 | CYA_1242 | Identified by match to protein family HMM PF02219; Belongs to the methylenetetrahydrofolate reductase family. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.931 |
| CYA_1304 | glyA | CYA_1304 | CYA_2015 | Identified by match to protein family HMM PF02219; Belongs to the methylenetetrahydrofolate reductase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.950 |
| CYA_1304 | lpdA | CYA_1304 | CYA_2059 | Identified by match to protein family HMM PF02219; Belongs to the methylenetetrahydrofolate reductase family. | Dihydrolipoamide dehydrogenase; Identified by match to protein family HMM PF00070; match to protein family HMM PF01134; match to protein family HMM PF01266; match to protein family HMM PF02852; match to protein family HMM PF07992; match to protein family HMM TIGR01350. | 0.919 |
| CYA_1304 | metH | CYA_1304 | CYA_2411 | Identified by match to protein family HMM PF02219; Belongs to the methylenetetrahydrofolate reductase family. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.998 |
| CYA_1304 | metK | CYA_1304 | CYA_1186 | Identified by match to protein family HMM PF02219; Belongs to the methylenetetrahydrofolate reductase family. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.793 |
| CYA_1304 | thyX | CYA_1304 | CYA_0237 | Identified by match to protein family HMM PF02219; Belongs to the methylenetetrahydrofolate reductase family. | Thymidylate synthase, flavin-dependent; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | 0.906 |
| CYA_2579 | CYA_1304 | CYA_2579 | CYA_1304 | Iron-sulfur cluster-binding protein; Identified by match to protein family HMM PF00037. | Identified by match to protein family HMM PF02219; Belongs to the methylenetetrahydrofolate reductase family. | 0.852 |
| CYA_2579 | gcvP | CYA_2579 | CYA_2098 | Iron-sulfur cluster-binding protein; Identified by match to protein family HMM PF00037. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.573 |
| CYA_2579 | metH | CYA_2579 | CYA_2411 | Iron-sulfur cluster-binding protein; Identified by match to protein family HMM PF00037. | Methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.962 |
| CYA_2579 | metK | CYA_2579 | CYA_1186 | Iron-sulfur cluster-binding protein; Identified by match to protein family HMM PF00037. | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.713 |
| folD | CYA_1304 | CYA_1974 | CYA_1304 | FolD bifunctional protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Identified by match to protein family HMM PF02219; Belongs to the methylenetetrahydrofolate reductase family. | 0.934 |
| folD | gcvH | CYA_1974 | CYA_0482 | FolD bifunctional protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.952 |
| folD | gcvP | CYA_1974 | CYA_2098 | FolD bifunctional protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.985 |
| folD | gcvT | CYA_1974 | CYA_1242 | FolD bifunctional protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine. | 0.957 |
| folD | glyA | CYA_1974 | CYA_2015 | FolD bifunctional protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.987 |
| folD | lpdA | CYA_1974 | CYA_2059 | FolD bifunctional protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Dihydrolipoamide dehydrogenase; Identified by match to protein family HMM PF00070; match to protein family HMM PF01134; match to protein family HMM PF01266; match to protein family HMM PF02852; match to protein family HMM PF07992; match to protein family HMM TIGR01350. | 0.934 |
