node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SDL85589.1 | SDL85626.1 | SAMN04488692_11068 | SAMN04488692_11069 | Uri superfamily endonuclease. | DNA helicase-2 / ATP-dependent DNA helicase PcrA. | 0.775 |
SDL85589.1 | gatA | SAMN04488692_11068 | SAMN04488692_11072 | Uri superfamily endonuclease. | aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit A; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). | 0.665 |
SDL85589.1 | gatB | SAMN04488692_11068 | SAMN04488692_11073 | Uri superfamily endonuclease. | aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatB/GatE family. GatB subfamily. | 0.620 |
SDL85589.1 | gatC | SAMN04488692_11068 | SAMN04488692_11071 | Uri superfamily endonuclease. | aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatC family. | 0.693 |
SDL85589.1 | hisB | SAMN04488692_11068 | SAMN04488692_11063 | Uri superfamily endonuclease. | Imidazoleglycerol-phosphate dehydratase. | 0.554 |
SDL85589.1 | hisD | SAMN04488692_11068 | SAMN04488692_11062 | Uri superfamily endonuclease. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.554 |
SDL85589.1 | hisG | SAMN04488692_11068 | SAMN04488692_11061 | Uri superfamily endonuclease. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.554 |
SDL85589.1 | hisI | SAMN04488692_11068 | SAMN04488692_11067 | Uri superfamily endonuclease. | phosphoribosyl-ATP pyrophosphatase; In the N-terminal section; belongs to the PRA-CH family. | 0.559 |
SDL85589.1 | hisZ | SAMN04488692_11068 | SAMN04488692_11060 | Uri superfamily endonuclease. | ATP phosphoribosyltransferase regulatory subunit; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. | 0.612 |
SDL85589.1 | ligA | SAMN04488692_11068 | SAMN04488692_11070 | Uri superfamily endonuclease. | DNA ligase (NAD+); DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. | 0.694 |
SDL85626.1 | SDL85589.1 | SAMN04488692_11069 | SAMN04488692_11068 | DNA helicase-2 / ATP-dependent DNA helicase PcrA. | Uri superfamily endonuclease. | 0.775 |
SDL85626.1 | gatA | SAMN04488692_11069 | SAMN04488692_11072 | DNA helicase-2 / ATP-dependent DNA helicase PcrA. | aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit A; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). | 0.817 |
SDL85626.1 | gatB | SAMN04488692_11069 | SAMN04488692_11073 | DNA helicase-2 / ATP-dependent DNA helicase PcrA. | aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatB/GatE family. GatB subfamily. | 0.803 |
SDL85626.1 | gatC | SAMN04488692_11069 | SAMN04488692_11071 | DNA helicase-2 / ATP-dependent DNA helicase PcrA. | aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatC family. | 0.865 |
SDL85626.1 | hisB | SAMN04488692_11069 | SAMN04488692_11063 | DNA helicase-2 / ATP-dependent DNA helicase PcrA. | Imidazoleglycerol-phosphate dehydratase. | 0.654 |
SDL85626.1 | hisD | SAMN04488692_11069 | SAMN04488692_11062 | DNA helicase-2 / ATP-dependent DNA helicase PcrA. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.621 |
SDL85626.1 | hisG | SAMN04488692_11069 | SAMN04488692_11061 | DNA helicase-2 / ATP-dependent DNA helicase PcrA. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.583 |
SDL85626.1 | hisI | SAMN04488692_11069 | SAMN04488692_11067 | DNA helicase-2 / ATP-dependent DNA helicase PcrA. | phosphoribosyl-ATP pyrophosphatase; In the N-terminal section; belongs to the PRA-CH family. | 0.753 |
SDL85626.1 | hisZ | SAMN04488692_11069 | SAMN04488692_11060 | DNA helicase-2 / ATP-dependent DNA helicase PcrA. | ATP phosphoribosyltransferase regulatory subunit; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. | 0.620 |
SDL85626.1 | ligA | SAMN04488692_11069 | SAMN04488692_11070 | DNA helicase-2 / ATP-dependent DNA helicase PcrA. | DNA ligase (NAD+); DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. | 0.961 |