PHYPA_027780 protein (Physcomitrella patens)

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second shell of interactors

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a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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Score

PHYPA_027780

Lipase_3 domain-containing protein. (934 aa)

Predicted Functional Partners:

PHYPA_021768

0.525

PHYPA_018371

0.524

PHYPA_019906

0.497

PHYPA_002578

0.496

PHYPA_016206

0.489

PHYPA_015913

0.473

PHYPA_027394

0.468

PHYPA_006388

0.467

PHYPA_022607

0.463

PHYPA_016048

0.461

Your Current Organism:

Physcomitrella patens

NCBI taxonomy Id: 3218
Other names: P. patens, Physcomitrella patens (Hedw.) Bruch & Schimp., Physcomitrella patens subsp. patens, Physcomitrium patens, Physcomitrium patens (Hedw.) Mitt.

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PHYPA_002578	PHYPA_015913	A9T8E7	A9S8P0	Predicted protein; Belongs to the adaptor complexes medium subunit family.	Predicted protein.	0.406
PHYPA_002578	PHYPA_016206	A9T8E7	A0A2K1JQK9	Predicted protein; Belongs to the adaptor complexes medium subunit family.	Fmp27_GFWDK domain-containing protein.	0.466
PHYPA_002578	PHYPA_018371	A9T8E7	A0A2K1JHE6	Predicted protein; Belongs to the adaptor complexes medium subunit family.	Uncharacterized protein.	0.500
PHYPA_002578	PHYPA_019906	A9T8E7	A0A2K1JDM6	Predicted protein; Belongs to the adaptor complexes medium subunit family.	SH3 domain-containing protein.	0.421
PHYPA_002578	PHYPA_021768	A9T8E7	A0A2K1J311	Predicted protein; Belongs to the adaptor complexes medium subunit family.	Uncharacterized protein.	0.501
PHYPA_002578	PHYPA_027394	A9T8E7	A0A2K1IP97	Predicted protein; Belongs to the adaptor complexes medium subunit family.	Uncharacterized protein.	0.400
PHYPA_002578	PHYPA_027780	A9T8E7	A0A2K1III3	Predicted protein; Belongs to the adaptor complexes medium subunit family.	Lipase_3 domain-containing protein.	0.496
PHYPA_006388	PHYPA_016206	A0A2K1KP04	A0A2K1JQK9	F-box domain-containing protein.	Fmp27_GFWDK domain-containing protein.	0.465
PHYPA_006388	PHYPA_018371	A0A2K1KP04	A0A2K1JHE6	F-box domain-containing protein.	Uncharacterized protein.	0.497
PHYPA_006388	PHYPA_019906	A0A2K1KP04	A0A2K1JDM6	F-box domain-containing protein.	SH3 domain-containing protein.	0.483
PHYPA_006388	PHYPA_021768	A0A2K1KP04	A0A2K1J311	F-box domain-containing protein.	Uncharacterized protein.	0.499
PHYPA_006388	PHYPA_027780	A0A2K1KP04	A0A2K1III3	F-box domain-containing protein.	Lipase_3 domain-containing protein.	0.467
PHYPA_015913	PHYPA_002578	A9S8P0	A9T8E7	Predicted protein.	Predicted protein; Belongs to the adaptor complexes medium subunit family.	0.406
PHYPA_015913	PHYPA_016206	A9S8P0	A0A2K1JQK9	Predicted protein.	Fmp27_GFWDK domain-containing protein.	0.472
PHYPA_015913	PHYPA_018371	A9S8P0	A0A2K1JHE6	Predicted protein.	Uncharacterized protein.	0.452
PHYPA_015913	PHYPA_021768	A9S8P0	A0A2K1J311	Predicted protein.	Uncharacterized protein.	0.453
PHYPA_015913	PHYPA_027780	A9S8P0	A0A2K1III3	Predicted protein.	Lipase_3 domain-containing protein.	0.473
PHYPA_016048	PHYPA_016206	A0A2K1JQG2	A0A2K1JQK9	F-box domain-containing protein.	Fmp27_GFWDK domain-containing protein.	0.453
PHYPA_016048	PHYPA_018371	A0A2K1JQG2	A0A2K1JHE6	F-box domain-containing protein.	Uncharacterized protein.	0.491
PHYPA_016048	PHYPA_019906	A0A2K1JQG2	A0A2K1JDM6	F-box domain-containing protein.	SH3 domain-containing protein.	0.488

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

15

average node degree:

2.73

avg. local clustering coefficient:

0.889

expected number of edges:

13

PPI enrichment p-value:

0.31

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0034198

Cellular response to amino acid starvation

8 of 20

2.75

8.5

1.91e-17

GO:1903432

Regulation of TORC1 signaling

9 of 41

2.49

8.11

6.04e-18

GO:0031669

Cellular response to nutrient levels

9 of 101

2.09

5.9

2.22e-15

GO:0051445

Regulation of meiotic cell cycle

5 of 16

2.64

4.85

5.00e-10

GO:0010508

Positive regulation of autophagy

6 of 52

2.21

4.4

4.14e-10

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0035859

Seh1-associated complex

8 of 8

3.14

10.42

3.00e-20

GO:0061700

GATOR2 complex

6 of 6

3.14

7.51

1.26e-14

GO:0044754

Autolysosome

5 of 14

2.7

5.17

1.35e-10

GO:0005764

Lysosome

8 of 119

1.97

4.75

7.66e-13

GO:0005773

Vacuole

9 of 171

1.87

4.63

6.66e-14

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:12613

Cellular response to amino acid starvation

9 of 13

2.98

11.08

5.12e-22

CL:12608

Regulation of TOR signaling, and TOR complex

10 of 47

2.47

9.34

2.90e-21

CL:12616

Seh1-associated complex

6 of 6

3.14

7.69

5.71e-15

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

ame04150

mTOR signaling pathway

9 of 73

2.23

7.09

1.66e-17

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-9639288

Amino acids regulate mTORC1

8 of 56

2.3

6.3

1.32e-14

MAP-9711097

Cellular response to starvation

8 of 61

2.26

6.2

1.32e-14

MAP-2262752

Cellular responses to stress

10 of 470

1.47

2.81

4.05e-12

MAP-8953897

Cellular responses to stimuli

10 of 478

1.46

2.79

4.05e-12

MAP-3371556

Cellular response to heat stress

3 of 81

1.71

1.06

0.0070

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0035859

Seh1-associated complex

7 of 8

3.09

8.62

7.54e-17

GOCC:1990130

GATOR1 complex

3 of 3

3.14

2.98

3.85e-06

GOCC:0061700

GATOR2 complex

2 of 3

2.97

1.55

0.0016

GOCC:0032991

Protein-containing complex

10 of 3072

0.66

0.55

0.00045

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0853

WD repeat

4 of 164

1.53

1.26

0.0013

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00320

WD40 repeats

5 of 196

1.55

1.65

8.83e-05

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