PHYPA_028172 protein (Physcomitrella patens)

Nodes:

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second shell of interactors

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

PHYPA_028172

Uncharacterized protein. (108 aa)

Predicted Functional Partners:

PHYPA_017356

0.527

PHYPA_025473

0.516

PHYPA_005599

0.516

PHYPA_006404

0.513

PHYPA_016336

0.511

PHYPA_003601

0.483

PHYPA_010750

0.481

PHYPA_013193

0.479

PHYPA_003866

0.473

PHYPA_027528

0.468

Your Current Organism:

Physcomitrella patens

NCBI taxonomy Id: 3218
Other names: P. patens, Physcomitrella patens (Hedw.) Bruch & Schimp., Physcomitrella patens subsp. patens, Physcomitrium patens, Physcomitrium patens (Hedw.) Mitt.

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PHYPA_003601	PHYPA_003866	A0A2K1L446	A0A2K1KSV4	Uncharacterized protein.	Uncharacterized protein.	0.496
PHYPA_003601	PHYPA_005599	A0A2K1L446	A0A2K1KLP8	Uncharacterized protein.	Uncharacterized protein.	0.521
PHYPA_003601	PHYPA_010750	A0A2K1L446	A0A2K1KCQ3	Uncharacterized protein.	Uncharacterized protein.	0.456
PHYPA_003601	PHYPA_017356	A0A2K1L446	A0A2K1JMC6	Uncharacterized protein.	Uncharacterized protein.	0.467
PHYPA_003601	PHYPA_025473	A0A2K1L446	A0A2K1IW80	Uncharacterized protein.	Uncharacterized protein.	0.412
PHYPA_003601	PHYPA_027528	A0A2K1L446	A0A2K1IHT1	Uncharacterized protein.	Uncharacterized protein.	0.450
PHYPA_003601	PHYPA_028172	A0A2K1L446	A0A2K1IJN1	Uncharacterized protein.	Uncharacterized protein.	0.483
PHYPA_003866	PHYPA_003601	A0A2K1KSV4	A0A2K1L446	Uncharacterized protein.	Uncharacterized protein.	0.496
PHYPA_003866	PHYPA_005599	A0A2K1KSV4	A0A2K1KLP8	Uncharacterized protein.	Uncharacterized protein.	0.486
PHYPA_003866	PHYPA_006404	A0A2K1KSV4	A0A2K1KP17	Uncharacterized protein.	Uncharacterized protein.	0.466
PHYPA_003866	PHYPA_010750	A0A2K1KSV4	A0A2K1KCQ3	Uncharacterized protein.	Uncharacterized protein.	0.428
PHYPA_003866	PHYPA_013193	A0A2K1KSV4	A0A2K1K4L6	Uncharacterized protein.	Uncharacterized protein.	0.458
PHYPA_003866	PHYPA_016336	A0A2K1KSV4	A0A2K1JQZ1	Uncharacterized protein.	Uncharacterized protein.	0.519
PHYPA_003866	PHYPA_017356	A0A2K1KSV4	A0A2K1JMC6	Uncharacterized protein.	Uncharacterized protein.	0.484
PHYPA_003866	PHYPA_025473	A0A2K1KSV4	A0A2K1IW80	Uncharacterized protein.	Uncharacterized protein.	0.513
PHYPA_003866	PHYPA_027528	A0A2K1KSV4	A0A2K1IHT1	Uncharacterized protein.	Uncharacterized protein.	0.480
PHYPA_003866	PHYPA_028172	A0A2K1KSV4	A0A2K1IJN1	Uncharacterized protein.	Uncharacterized protein.	0.473
PHYPA_005599	PHYPA_003601	A0A2K1KLP8	A0A2K1L446	Uncharacterized protein.	Uncharacterized protein.	0.521
PHYPA_005599	PHYPA_003866	A0A2K1KLP8	A0A2K1KSV4	Uncharacterized protein.	Uncharacterized protein.	0.486
PHYPA_005599	PHYPA_006404	A0A2K1KLP8	A0A2K1KP17	Uncharacterized protein.	Uncharacterized protein.	0.457

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

46

average node degree:

8.36

avg. local clustering coefficient:

0.917

expected number of edges:

14

PPI enrichment p-value:

2.83e-11

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006631

Fatty acid metabolic process

4 of 24

1.61

1.17

0.0030

GO:0019605

Butyrate metabolic process

2 of 2

2.39

0.84

0.0286

GO:0017000

Antibiotic biosynthetic process

3 of 17

1.64

0.77

0.0286

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031177

Phosphopantetheine binding

3 of 3

2.39

1.74

0.00056

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1312

Mixed, incl. AMP-binding enzyme, and Butyrate metabolic process

7 of 10

2.24

5.06

1.07e-11

CL:1286

Mixed, incl. Fatty acid metabolism, and KR domain

8 of 23

1.93

4.31

1.07e-11

CL:1314

AMP-binding enzyme, and Polyketide synthase, ketoreductase domain

3 of 5

2.17

1.84

0.00028

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005777

Peroxisome

4 of 6

2.21

2.6

7.15e-06

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0596

Phosphopantetheine

2 of 4

2.09

0.74

0.0420

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00550

Phosphopantetheine attachment site

5 of 8

2.19

3.27

2.05e-07

PF16197

Ketoacyl-synthetase C-terminal extension

3 of 3

2.39

1.96

0.00021

PF02801

Beta-ketoacyl synthase, C-terminal domain

3 of 4

2.27

1.9

0.00024

PF00109

Beta-ketoacyl synthase, N-terminal domain

3 of 4

2.27

1.9

0.00024

PF00501

AMP-binding enzyme

2 of 4

2.09

0.92

0.0190

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036736

ACP-like superfamily

5 of 8

2.19

3.09

5.38e-07

IPR009081

Phosphopantetheine binding ACP domain

5 of 8

2.19

3.09

5.38e-07

IPR032821

Polyketide synthase, C-terminal extension

3 of 3

2.39

1.83

0.00037

IPR020841

Polyketide synthase, beta-ketoacyl synthase domain

3 of 4

2.27

1.75

0.00048

IPR018201

Beta-ketoacyl synthase, active site

3 of 4

2.27

1.75

0.00048

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00822

This enzymatic domain is part of bacterial polyketide synthases and catalyses the first step in the reductive modification of the beta-carbonyl centres in the growing polyketide chain. It uses NADPH to reduce the keto group to a hydroxy group.

2 of 2

2.39

1.09

0.0097

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