PHYPA_026979 protein (Physcomitrella patens)

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second shell of interactors

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filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Cooccurrence

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[Homology]

Score

PHYPA_026979

Uncharacterized protein. (360 aa)

Predicted Functional Partners:

PHYPA_009964

0.978

PHYPA_007863

0.972

PHYPA_028306

0.951

PHYPA_028225

0.947

PHYPA_013531

0.935

PHYPA_001248

0.935

PHYPA_023096

0.915

PHYPA_006043

0.915

PHYPA_011255

0.732

PHYPA_005146

0.717

Your Current Organism:

Physcomitrella patens

NCBI taxonomy Id: 3218
Other names: P. patens, Physcomitrella patens (Hedw.) Bruch & Schimp., Physcomitrella patens subsp. patens, Physcomitrium patens, Physcomitrium patens (Hedw.) Mitt.

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PHYPA_001248	PHYPA_005146	A0A2K1L9X0	A9S829	DAGKc domain-containing protein.	Predicted protein.	0.940
PHYPA_001248	PHYPA_006043	A0A2K1L9X0	A0A2K1KMZ5	DAGKc domain-containing protein.	Neutral ceramidase.	0.938
PHYPA_001248	PHYPA_007863	A0A2K1L9X0	A0A2K1KK84	DAGKc domain-containing protein.	Aminotran_1_2 domain-containing protein.	0.409
PHYPA_001248	PHYPA_009964	A0A2K1L9X0	A9TT57	DAGKc domain-containing protein.	Predicted protein.	0.513
PHYPA_001248	PHYPA_011255	A0A2K1L9X0	A0A2K1K6F7	DAGKc domain-containing protein.	Uncharacterized protein.	0.409
PHYPA_001248	PHYPA_013531	A0A2K1L9X0	A0A2K1JY07	DAGKc domain-containing protein.	DAGKc domain-containing protein.	0.901
PHYPA_001248	PHYPA_023096	A0A2K1L9X0	A0A2K1J0Z7	DAGKc domain-containing protein.	Neutral ceramidase.	0.938
PHYPA_001248	PHYPA_026979	A0A2K1L9X0	A0A2K1IN09	DAGKc domain-containing protein.	Uncharacterized protein.	0.935
PHYPA_001248	PHYPA_028225	A0A2K1L9X0	A9TFV8	DAGKc domain-containing protein.	Predicted protein; Belongs to the sterol desaturase family.	0.955
PHYPA_001248	PHYPA_028306	A0A2K1L9X0	A0A2K1IK09	DAGKc domain-containing protein.	Sphingolipid delta(4)-desaturase DES1-like; Sphingolipid-delta-4-desaturase required for the biosynthesis of delta-4-unsaturated sphingolipids and derivatives.	0.939
PHYPA_005146	PHYPA_001248	A9S829	A0A2K1L9X0	Predicted protein.	DAGKc domain-containing protein.	0.940
PHYPA_005146	PHYPA_006043	A9S829	A0A2K1KMZ5	Predicted protein.	Neutral ceramidase.	0.923
PHYPA_005146	PHYPA_007863	A9S829	A0A2K1KK84	Predicted protein.	Aminotran_1_2 domain-containing protein.	0.427
PHYPA_005146	PHYPA_009964	A9S829	A9TT57	Predicted protein.	Predicted protein.	0.481
PHYPA_005146	PHYPA_011255	A9S829	A0A2K1K6F7	Predicted protein.	Uncharacterized protein.	0.427
PHYPA_005146	PHYPA_013531	A9S829	A0A2K1JY07	Predicted protein.	DAGKc domain-containing protein.	0.940
PHYPA_005146	PHYPA_023096	A9S829	A0A2K1J0Z7	Predicted protein.	Neutral ceramidase.	0.923
PHYPA_005146	PHYPA_026979	A9S829	A0A2K1IN09	Predicted protein.	Uncharacterized protein.	0.717
PHYPA_005146	PHYPA_028225	A9S829	A9TFV8	Predicted protein.	Predicted protein; Belongs to the sterol desaturase family.	0.932
PHYPA_005146	PHYPA_028306	A9S829	A0A2K1IK09	Predicted protein.	Sphingolipid delta(4)-desaturase DES1-like; Sphingolipid-delta-4-desaturase required for the biosynthesis of delta-4-unsaturated sphingolipids and derivatives.	0.940

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

36

average node degree:

6.55

avg. local clustering coefficient:

0.715

expected number of edges:

36

PPI enrichment p-value:

0.514

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0007186

G protein-coupled receptor signaling pathway

6 of 131

1.92

2.98

1.77e-07

GO:0048312

Intracellular distribution of mitochondria

2 of 4

2.96

1.53

0.0017

GO:1902115

Regulation of organelle assembly

3 of 50

2.04

1.48

0.0013

GO:1900242

Regulation of synaptic vesicle endocytosis

2 of 5

2.87

1.48

0.0021

GO:0007154

Cell communication

9 of 1248

1.12

1.33

1.51e-06

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030159

Signaling receptor complex adaptor activity

3 of 22

2.4

1.78

0.00047

GO:0001965

G-protein alpha-subunit binding

2 of 5

2.87

1.38

0.0032

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005834

Heterotrimeric G-protein complex

4 of 13

2.75

3.74

1.08e-07

GO:0044297

Cell body

2 of 26

2.15

1.18

0.0061

GO:0043195

Terminal bouton

2 of 23

2.2

1.18

0.0061

GO:0071944

Cell periphery

7 of 1721

0.87

0.74

0.00070

GO:0005770

Late endosome

2 of 83

1.65

0.69

0.0426

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:10680

GPCR ligand binding, and Regulation of G protein-coupled receptor signaling pathway

7 of 75

2.23

5.07

1.03e-11

CL:10782

RGS domain, and GTPase complex

5 of 20

2.66

4.96

3.29e-10

CL:10783

RGS domain, and GTPase complex

4 of 13

2.75

4.01

3.19e-08

CL:344

Intracellular distribution of mitochondria, and Immunoglobulin V-set domain

2 of 5

2.87

1.57

0.0014

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-418594

G alpha (i) signalling events

6 of 83

2.12

4.03

1.67e-09

MAP-372790

Signaling by GPCR

7 of 156

1.92

3.73

7.50e-10

MAP-373080

Class B/2 (Secretin family receptors)

3 of 4

3.14

3.25

1.25e-06

MAP-202040

G-protein activation

3 of 4

3.14

3.25

1.25e-06

MAP-397795

G-protein beta:gamma signalling

3 of 7

2.9

3.09

2.14e-06

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0098562

Cytoplasmic side of membrane

5 of 27

2.53

4.37

3.37e-09

GOCC:0005834

Heterotrimeric G-protein complex

3 of 11

2.7

2.73

8.88e-06

GOCC:0032473

Cytoplasmic side of mitochondrial outer membrane

2 of 2

3.26

2.12

0.00015

GOCC:0071944

Cell periphery

8 of 696

1.32

1.87

1.07e-07

GOCC:0005886

Plasma membrane

7 of 614

1.32

1.68

1.90e-06

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0853

WD repeat

3 of 130

1.63

0.96

0.0102

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR016346

Guanine nucleotide-binding protein, beta subunit

3 of 3

3.26

2.84

7.33e-06

IPR001632

G-protein, beta subunit

2 of 2

3.26

1.45

0.0025

IPR019775

WD40 repeat, conserved site

3 of 65

1.93

1.14

0.0060

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00320

WD40 repeats

3 of 161

1.53

0.73

0.0327

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