PHYPA_007447 protein (Physcomitrella patens)

Nodes:

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second shell of interactors

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filled nodes:
a 3D structure is known or predicted

Edges:

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Cooccurrence

Coexpression

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[Homology]

Score

PHYPA_007447

Uncharacterized protein. (625 aa)

Predicted Functional Partners:

PHYPA_007729

0.426

PpRpoA2

0.426

PHYPA_011898

0.420

PHYPA_020905

0.419

PHYPA_007267

0.419

PHYPA_009414

0.419

Your Current Organism:

Physcomitrella patens

NCBI taxonomy Id: 3218
Other names: P. patens, Physcomitrella patens (Hedw.) Bruch & Schimp., Physcomitrella patens subsp. patens, Physcomitrium patens, Physcomitrium patens (Hedw.) Mitt.

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PHYPA_007267	PHYPA_007447	A9S185	A0A2K1KJ11	Predicted protein.	Uncharacterized protein.	0.419
PHYPA_007447	PHYPA_007267	A0A2K1KJ11	A9S185	Uncharacterized protein.	Predicted protein.	0.419
PHYPA_007447	PHYPA_007729	A0A2K1KJ11	A0A2K1KJX0	Uncharacterized protein.	RPOLD domain-containing protein.	0.426
PHYPA_007447	PHYPA_009414	A0A2K1KJ11	A9S7D8	Uncharacterized protein.	Predicted protein.	0.419
PHYPA_007447	PHYPA_011898	A0A2K1KJ11	A0A2K1K8A3	Uncharacterized protein.	SET domain-containing protein.	0.420
PHYPA_007447	PHYPA_020905	A0A2K1KJ11	A9RL53	Uncharacterized protein.	Predicted protein.	0.419
PHYPA_007447	PpRpoA2	A0A2K1KJ11	A9CP51	Uncharacterized protein.	DNA-directed RNA polymerase alpha chain.	0.426
PHYPA_007729	PHYPA_007447	A0A2K1KJX0	A0A2K1KJ11	RPOLD domain-containing protein.	Uncharacterized protein.	0.426
PHYPA_007729	PHYPA_011898	A0A2K1KJX0	A0A2K1K8A3	RPOLD domain-containing protein.	SET domain-containing protein.	0.433
PHYPA_007729	PpRpoA2	A0A2K1KJX0	A9CP51	RPOLD domain-containing protein.	DNA-directed RNA polymerase alpha chain.	0.903
PHYPA_009414	PHYPA_007447	A9S7D8	A0A2K1KJ11	Predicted protein.	Uncharacterized protein.	0.419
PHYPA_011898	PHYPA_007447	A0A2K1K8A3	A0A2K1KJ11	SET domain-containing protein.	Uncharacterized protein.	0.420
PHYPA_011898	PHYPA_007729	A0A2K1K8A3	A0A2K1KJX0	SET domain-containing protein.	RPOLD domain-containing protein.	0.433
PHYPA_011898	PpRpoA2	A0A2K1K8A3	A9CP51	SET domain-containing protein.	DNA-directed RNA polymerase alpha chain.	0.433
PHYPA_020905	PHYPA_007447	A9RL53	A0A2K1KJ11	Predicted protein.	Uncharacterized protein.	0.419
PpRpoA2	PHYPA_007447	A9CP51	A0A2K1KJ11	DNA-directed RNA polymerase alpha chain.	Uncharacterized protein.	0.426
PpRpoA2	PHYPA_007729	A9CP51	A0A2K1KJX0	DNA-directed RNA polymerase alpha chain.	RPOLD domain-containing protein.	0.903
PpRpoA2	PHYPA_011898	A9CP51	A0A2K1K8A3	DNA-directed RNA polymerase alpha chain.	SET domain-containing protein.	0.433

Network Stats

number of nodes:

11

number of edges:

42

average node degree:

7.64

avg. local clustering coefficient:

0.779

expected number of edges:

12

PPI enrichment p-value:

6.82e-12

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0007031

Peroxisome organization

3 of 26

2.18

1.35

0.0040

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004867

Serine-type endopeptidase inhibitor activity

2 of 2

3.12

1.36

0.0050

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005778

Peroxisomal membrane

3 of 26

2.18

1.68

0.00092

GO:0005779

Integral component of peroxisomal membrane

2 of 8

2.51

1.28

0.0064

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:7259

Mixed, incl. Serine-type endopeptidase inhibitor activity, and ACT domain

5 of 11

2.77

5.42

2.36e-10

CL:7251

Mixed, incl. NodB homology domain, and Serine-type endopeptidase activity

6 of 33

2.38

5.09

1.44e-10

CL:7271

Mixed, incl. ACT domain, and Peroxin domain

4 of 5

3.02

4.84

4.29e-09

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005778

Peroxisomal membrane

5 of 65

2.0

2.98

7.83e-07

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF10000

ACT domain

2 of 2

3.12

1.47

0.0033

PF06398

Integral peroxisomal membrane peroxin

2 of 2

3.12

1.47

0.0033

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR018717

Domain of unknown function DUF2241

2 of 2

3.12

1.21

0.0092

IPR010482

Peroxin domain

2 of 2

3.12

1.21

0.0092

IPR045865

ACT-like domain

2 of 9

2.46

0.91

0.0281

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