STRINGSTRING
FEN1-B protein (Physcomitrella patens) - STRING interaction network
"FEN1-B" - Flap endonuclease 1-B in Physcomitrella patens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
FEN1-BFlap endonuclease 1-B; Structure-specific nuclease with 5’-flap endonuclease and 5’-3’ exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5’-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5’-end of a downstream Okazaki fragment. It enters the flap from the 5’-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as [...] (394 aa)    
Predicted Functional Partners:
PP1S46_194V6.1
Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase’s processibility during elongation of the leading strand (263 aa)
     
  0.993
PP1S227_112V6.1
Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase’s processibility during elongation of the leading strand (224 aa)
     
  0.992
PP1S18_235V6.1
Predicted protein (716 aa)
   
  0.984
PP1S251_77V6.1
Predicted protein; Component of the post-replicative DNA mismatch repair system (MMR) (951 aa)
   
  0.979
PP1S16_395V6.1
Annotation not available (276 aa)
   
  0.979
PP1S96_143V6.1
Predicted protein (338 aa)
   
  0.976
PP1S225_68V6.1
Predicted protein (992 aa)
   
  0.971
PP1S88_44V6.1
Predicted protein (354 aa)
   
  0.968
PP1S58_199V6.1
Predicted protein (723 aa)
   
  0.965
PP1S93_66V6.1
Annotation not available (890 aa)
   
  0.955
Your Current Organism:
Physcomitrella patens
NCBI taxonomy Id: 3218
Other names: Bryophyta, Bryophytina, Bryopsida, Funariaceae, Funariales, Funariidae, Moss Superclass V, Musci, P. patens, Physcomitrella, Physcomitrella Bruch & Schimp, Physcomitrella patens, Physcomitrella patens (Hedw.) Bruch & Schimp., Physcomitrium patens, Physcomitrium patens (Hedw.) Mitt., bryophytes, mosses
Server load: low (6%) [HD]