STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LSEI_0960Hypothetical protein; Required for morphogenesis under gluconeogenic growth conditions; Belongs to the gluconeogenesis factor family. (342 aa)    
Predicted Functional Partners:
whiA
Hypothetical protein; Involved in cell division and chromosome segregation.
 
  
 0.972
LSEI_0959
Predicted P-loop-containing kinase; Displays ATPase and GTPase activities.
  
  
 0.971
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
   
   0.784
uvrA
Excinuclease ABC subunit A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate.
       0.611
LSEI_1623
Serine/threonine protein phosphatase.
   
  
 0.607
uvrB
Excinuclease ABC subunit B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...]
       0.571
LSEI_0574
Hypothetical protein.
   
  
 0.543
LSEI_0247
Transcriptional regulator.
  
     0.538
LSEI_0958
Hypothetical protein.
       0.522
LSEI_2241
Transcriptional regulator.
  
     0.518
Your Current Organism:
Lactobacillus paracasei
NCBI taxonomy Id: 321967
Other names: L. paracasei ATCC 334, Lactobacillus casei ATCC 334, Lactobacillus casei str. ATCC 334, Lactobacillus casei strain ATCC 334, Lactobacillus paracasei ATCC 334
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.