Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
LSEI_2139Sortase (surface protein transpeptidase). (233 aa)    
Predicted Functional Partners:
LSEI_0795
D-alanyl transfer protein; Could be involved in the transport of activated D-alanine through the membrane.
      
 0.655
gyrA
DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
  
  
 0.645
secA
Protein translocase subunit secA; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.
      
 0.637
LSEI_2138
Predicted permease.
 
     0.625
LSEI_0457
Sortase (surface protein transpeptidase).
 
   
 0.616
LSEI_1677
Preprotein translocase subunit YidC.
 
   
 0.587
LSEI_2137
Beta-lactamase class C related penicillin binding protein.
       0.550
LSEI_2362
Sortase (surface protein transpeptidase).
 
   
 0.542
LSEI_1360
5'-nucleotidase/2',3'-cyclic phosphodiesterase related esterase; Belongs to the 5'-nucleotidase family.
   
  
 0.530
yidC
Preprotein translocase subunit YidC; Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins; Belongs to the OXA1/ALB3/YidC family. Type 2 subfamily.
 
   
 0.529
Your Current Organism:
Lactobacillus paracasei
NCBI taxonomy Id: 321967
Other names: L. paracasei ATCC 334, Lactobacillus casei ATCC 334, Lactobacillus casei str. ATCC 334, Lactobacillus casei strain ATCC 334, Lactobacillus paracasei ATCC 334
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