STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
HSM3DNA mismatch repair protein HSM3; Involved in DNA mismatch repair in slow-growing cells. Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the 19S regulatory complex (RC) (By similarity); Belongs to the proteasome subunit S5B/HSM3 family. (497 aa)    
Predicted Functional Partners:
RPT1
Protease subunit component; Belongs to the AAA ATPase family.
    
 
 0.948
RPT5
26S proteasome regulatory subunit; Belongs to the AAA ATPase family.
   
 
 0.859
PRS4
26S protease regulatory subunit 4-like protein; Belongs to the AAA ATPase family.
    
 
 0.843
RPT3
26S proteasome regulatory subunit; Belongs to the AAA ATPase family.
   
 
 0.829
RPT6
Protease regulatory subunit 8 homolog (SUG1 protein) (CIM3 protein) (TAT-binding protein TBY1); Belongs to the AAA ATPase family.
    
 
 0.757
PICST_65037
26S proteasome regulatory subunit RPN1; Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.
    
 
 0.735
RPT4
26S protease subunit RPT4 (26S protease subunit SUG2) (Proteasomal cap subunit); Belongs to the AAA ATPase family.
   
 
 0.652
PICST_67290
Uncharacterized protein.
      
 0.650
PICST_76567
Nitrogen fixing protein.
      
 0.646
PICST_89414
PCI domain-containing protein.
    
 
 0.628
Your Current Organism:
Scheffersomyces stipitis
NCBI taxonomy Id: 322104
Other names: Pichia stipitis CBS 6054, S. stipitis CBS 6054, Scheffersomyces stipitis CBS 6054
Server load: low (14%) [HD]