node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SFD44200.1 | SFD45548.1 | SAMN04487836_101106 | SAMN04487836_101148 | Geranylgeranyl diphosphate synthase, type II; Belongs to the FPP/GGPP synthase family. | Ribonuclease J. | 0.625 |
SFD44200.1 | rnj | SAMN04487836_101106 | SAMN04487836_1106 | Geranylgeranyl diphosphate synthase, type II; Belongs to the FPP/GGPP synthase family. | Ribonuclease J; An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay. | 0.625 |
SFD44200.1 | topA | SAMN04487836_101106 | SAMN04487836_10225 | Geranylgeranyl diphosphate synthase, type II; Belongs to the FPP/GGPP synthase family. | DNA topoisomerase-1; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.413 |
SFD45514.1 | SFD45548.1 | SAMN04487836_101147 | SAMN04487836_101148 | DNA segregation ATPase FtsK/SpoIIIE, S-DNA-T family; Belongs to the FtsK/SpoIIIE/SftA family. | Ribonuclease J. | 0.814 |
SFD45514.1 | rnj | SAMN04487836_101147 | SAMN04487836_1106 | DNA segregation ATPase FtsK/SpoIIIE, S-DNA-T family; Belongs to the FtsK/SpoIIIE/SftA family. | Ribonuclease J; An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay. | 0.555 |
SFD45514.1 | topA | SAMN04487836_101147 | SAMN04487836_10225 | DNA segregation ATPase FtsK/SpoIIIE, S-DNA-T family; Belongs to the FtsK/SpoIIIE/SftA family. | DNA topoisomerase-1; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.617 |
SFD45548.1 | SFD44200.1 | SAMN04487836_101148 | SAMN04487836_101106 | Ribonuclease J. | Geranylgeranyl diphosphate synthase, type II; Belongs to the FPP/GGPP synthase family. | 0.625 |
SFD45548.1 | SFD45514.1 | SAMN04487836_101148 | SAMN04487836_101147 | Ribonuclease J. | DNA segregation ATPase FtsK/SpoIIIE, S-DNA-T family; Belongs to the FtsK/SpoIIIE/SftA family. | 0.814 |
SFD45548.1 | dapA | SAMN04487836_101148 | SAMN04487836_10458 | Ribonuclease J. | 4-hydroxy-tetrahydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). | 0.497 |
SFD45548.1 | infA | SAMN04487836_101148 | SAMN04487836_11520 | Ribonuclease J. | Translation initiation factor IF-1; One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex. | 0.463 |
SFD45548.1 | metG | SAMN04487836_101148 | SAMN04487836_104109 | Ribonuclease J. | methionyl-tRNA synthetase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. | 0.409 |
SFD45548.1 | rnj | SAMN04487836_101148 | SAMN04487836_1106 | Ribonuclease J. | Ribonuclease J; An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay. | 0.850 |
SFD45548.1 | topA | SAMN04487836_101148 | SAMN04487836_10225 | Ribonuclease J. | DNA topoisomerase-1; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.528 |
SFD83051.1 | SFD83100.1 | SAMN04487836_1105 | SAMN04487836_1107 | Calcineurin-like phosphoesterase. | EDD domain protein, DegV family. | 0.538 |
SFD83051.1 | mprF | SAMN04487836_1105 | SAMN04487836_1104 | Calcineurin-like phosphoesterase. | Conserved hypothetical protein; Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms. | 0.639 |
SFD83051.1 | rnj | SAMN04487836_1105 | SAMN04487836_1106 | Calcineurin-like phosphoesterase. | Ribonuclease J; An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay. | 0.773 |
SFD83100.1 | SFD83051.1 | SAMN04487836_1107 | SAMN04487836_1105 | EDD domain protein, DegV family. | Calcineurin-like phosphoesterase. | 0.538 |
SFD83100.1 | mprF | SAMN04487836_1107 | SAMN04487836_1104 | EDD domain protein, DegV family. | Conserved hypothetical protein; Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms. | 0.448 |
SFD83100.1 | rnj | SAMN04487836_1107 | SAMN04487836_1106 | EDD domain protein, DegV family. | Ribonuclease J; An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay. | 0.538 |
dapA | SFD45548.1 | SAMN04487836_10458 | SAMN04487836_101148 | 4-hydroxy-tetrahydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). | Ribonuclease J. | 0.497 |