T1KCF8_TETUR protein (Tetranychus urticae) - STRING interaction network

Nodes:

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second shell of interactors

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Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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Score

T1KCF8_TETUR

Non-specific serine/threonine protein kinase. (515 aa)

Predicted Functional Partners:

T1JRH9_TETUR

0.995

T1JTE3_TETUR

0.995

T1KXZ2_TETUR

0.975

T1JRX2_TETUR

0.971

T1K204_TETUR

0.970

T1KZ85_TETUR

0.965

T1KWD6_TETUR

0.956

T1KT87_TETUR

0.948

T1KRC7_TETUR

0.941

T1K9B7_TETUR

0.932

Your Current Organism:

Tetranychus urticae

NCBI taxonomy Id: 32264
Other names: T. urticae, red spider mite, two-spotted spider mite, twospotted mite

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
T1JRH9_TETUR	T1JRX2_TETUR	T1JRH9	T1JRX2	Uncharacterized protein.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.977
T1JRH9_TETUR	T1JTE3_TETUR	T1JRH9	T1JTE3	Uncharacterized protein.	AMPKBI domain-containing protein.	0.999
T1JRH9_TETUR	T1K204_TETUR	T1JRH9	T1K204	Uncharacterized protein.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.716
T1JRH9_TETUR	T1KCF8_TETUR	T1JRH9	T1KCF8	Uncharacterized protein.	Non-specific serine/threonine protein kinase.	0.995
T1JRH9_TETUR	T1KRC7_TETUR	T1JRH9	T1KRC7	Uncharacterized protein.	Fork-head domain-containing protein.	0.907
T1JRH9_TETUR	T1KT87_TETUR	T1JRH9	T1KT87	Uncharacterized protein.	Protein kinase domain-containing protein.	0.469
T1JRH9_TETUR	T1KWD6_TETUR	T1JRH9	T1KWD6	Uncharacterized protein.	Uncharacterized protein.	0.567
T1JRH9_TETUR	T1KXZ2_TETUR	T1JRH9	T1KXZ2	Uncharacterized protein.	WD_REPEATS_REGION domain-containing protein.	0.703
T1JRH9_TETUR	T1KZ85_TETUR	T1JRH9	T1KZ85	Uncharacterized protein.	Rap-GAP domain-containing protein.	0.672
T1JRX2_TETUR	T1JRH9_TETUR	T1JRX2	T1JRH9	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.977
T1JRX2_TETUR	T1JTE3_TETUR	T1JRX2	T1JTE3	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	AMPKBI domain-containing protein.	0.985
T1JRX2_TETUR	T1K204_TETUR	T1JRX2	T1K204	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.615
T1JRX2_TETUR	T1KCF8_TETUR	T1JRX2	T1KCF8	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase.	0.971
T1JRX2_TETUR	T1KRC7_TETUR	T1JRX2	T1KRC7	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Fork-head domain-containing protein.	0.955
T1JRX2_TETUR	T1KT87_TETUR	T1JRX2	T1KT87	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Protein kinase domain-containing protein.	0.992
T1JRX2_TETUR	T1KWD6_TETUR	T1JRX2	T1KWD6	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.993
T1JRX2_TETUR	T1KXZ2_TETUR	T1JRX2	T1KXZ2	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	WD_REPEATS_REGION domain-containing protein.	0.711
T1JRX2_TETUR	T1KZ85_TETUR	T1JRX2	T1KZ85	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Rap-GAP domain-containing protein.	0.728
T1JTE3_TETUR	T1JRH9_TETUR	T1JTE3	T1JRH9	AMPKBI domain-containing protein.	Uncharacterized protein.	0.999
T1JTE3_TETUR	T1JRX2_TETUR	T1JTE3	T1JRX2	AMPKBI domain-containing protein.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.985

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Network Stats

number of nodes:

11

number of edges:

23

average node degree:

4.18

avg. local clustering coefficient:

0.735

expected number of edges:

10

PPI enrichment p-value:

0.000502

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0015986

Proton motive force-driven ATP synthesis

7 of 22

2.68

6.72

7.27e-14

GO:1902600

Proton transmembrane transport

7 of 88

2.07

4.44

6.34e-11

GO:0042776

Proton motive force-driven mitochondrial ATP synthesis

4 of 12

2.7

3.81

7.16e-08

GO:0061469

Regulation of type B pancreatic cell proliferation

2 of 9

2.52

1.33

0.0036

GO:0006796

Phosphate-containing compound metabolic process

10 of 1477

1.0

1.19

1.27e-07

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0015078

Proton transmembrane transporter activity

7 of 89

2.07

4.29

1.62e-10

GO:0046933

Proton-transporting ATP synthase activity, rotational mechanism

4 of 10

2.78

3.68

1.46e-07

GO:0043027

Cysteine-type endopeptidase inhibitor activity involved in apoptotic process

2 of 10

2.48

1.19

0.0065

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005753

Mitochondrial proton-transporting ATP synthase complex

7 of 18

2.76

7.47

3.25e-15

GO:0032133

Chromosome passenger complex

4 of 7

2.93

4.35

9.43e-09

GO:0045261

Proton-transporting ATP synthase complex, catalytic core F(1)

3 of 5

2.95

3.16

1.64e-06

GO:0045263

Proton-transporting ATP synthase complex, coupling factor F(o)

3 of 12

2.57

2.65

1.11e-05

GO:0000275

Mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1)

2 of 3

3.0

1.98

0.00026

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:22668

Mitochondrial proton-transporting ATP synthase complex

7 of 13

2.91

7.82

1.38e-15

CL:22670

CF(1), and Formation of ATP by chemiosmotic coupling

5 of 6

3.09

5.83

1.85e-11

CL:8092

Mixed, incl. Spindle midzone, and Kinesin motor, catalytic domain. ATPase.

4 of 43

2.14

2.58

6.61e-06

CL:8120

Chromosome passenger complex, and Activation of NIMA Kinases NEK9, NEK6, NEK7

3 of 12

2.57

2.43

2.92e-05

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00190

Oxidative phosphorylation

8 of 166

1.86

4.18

4.21e-12

map01100

Metabolic pathways

8 of 2460

0.69

0.52

0.0027

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-163210

Formation of ATP by chemiosmotic coupling

7 of 18

2.76

7.43

4.12e-15

MAP-8949613

Cristae formation

7 of 27

2.59

6.82

2.30e-14

MAP-1592230

Mitochondrial biogenesis

7 of 50

2.32

5.69

7.50e-13

MAP-163200

Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.

7 of 120

1.94

3.97

1.87e-10

MAP-1428517

The citric acid (TCA) cycle and respiratory electron transport

7 of 178

1.77

3.26

2.17e-09

(more ...)

Tissue Expression (TISSUES)

tissue

description

count in network

strength

signal

false discovery rate

BTO:0000862

Heart ventricle

3 of 40

2.05

2.27

2.44e-05

BTO:0000562

Heart

4 of 233

1.41

1.53

5.79e-05

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0045259

Proton-transporting ATP synthase complex

7 of 29

2.56

6.57

6.48e-14

GOCC:0005753

Mitochondrial proton-transporting ATP synthase complex

4 of 11

2.73

3.81

7.47e-08

GOCC:0045261

Proton-transporting ATP synthase complex, catalytic core F(1)

4 of 14

2.63

3.66

1.25e-07

GOCC:0032133

Chromosome passenger complex

3 of 4

3.05

3.13

1.97e-06

GOCC:0045263

Proton-transporting ATP synthase complex, coupling factor F(o)

3 of 15

2.48

2.38

3.43e-05

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0375

Hydrogen ion transport

3 of 26

2.24

1.85

0.00029

KW-0139

CF(1)

2 of 4

2.87

1.63

0.0011

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00238

Baculoviral inhibition of apoptosis protein repeat

2 of 7

2.63

1.08

0.0109

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