| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ACO77089.1 | ACO77092.1 | Avin_08440 | Avin_08470 | Conserved hypothetical protein; Belongs to the UPF0250 family. | Hypothetical protein. | 0.752 |
| ACO77089.1 | ACO77093.1 | Avin_08440 | Avin_08480 | Conserved hypothetical protein; Belongs to the UPF0250 family. | Thiamine diphosphate-dependent enzyme; Belongs to the TPP enzyme family. | 0.752 |
| ACO77089.1 | lipA | Avin_08440 | Avin_08460 | Conserved hypothetical protein; Belongs to the UPF0250 family. | Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | 0.885 |
| ACO77089.1 | lipB | Avin_08440 | Avin_08450 | Conserved hypothetical protein; Belongs to the UPF0250 family. | Lipoate-protein ligase B; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. | 0.918 |
| ACO77092.1 | ACO77089.1 | Avin_08470 | Avin_08440 | Hypothetical protein. | Conserved hypothetical protein; Belongs to the UPF0250 family. | 0.752 |
| ACO77092.1 | ACO77093.1 | Avin_08470 | Avin_08480 | Hypothetical protein. | Thiamine diphosphate-dependent enzyme; Belongs to the TPP enzyme family. | 0.773 |
| ACO77092.1 | lipA | Avin_08470 | Avin_08460 | Hypothetical protein. | Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | 0.752 |
| ACO77092.1 | lipB | Avin_08470 | Avin_08450 | Hypothetical protein. | Lipoate-protein ligase B; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. | 0.752 |
| ACO77093.1 | ACO77089.1 | Avin_08480 | Avin_08440 | Thiamine diphosphate-dependent enzyme; Belongs to the TPP enzyme family. | Conserved hypothetical protein; Belongs to the UPF0250 family. | 0.752 |
| ACO77093.1 | ACO77092.1 | Avin_08480 | Avin_08470 | Thiamine diphosphate-dependent enzyme; Belongs to the TPP enzyme family. | Hypothetical protein. | 0.773 |
| ACO77093.1 | lipA | Avin_08480 | Avin_08460 | Thiamine diphosphate-dependent enzyme; Belongs to the TPP enzyme family. | Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | 0.757 |
| ACO77093.1 | lipB | Avin_08480 | Avin_08450 | Thiamine diphosphate-dependent enzyme; Belongs to the TPP enzyme family. | Lipoate-protein ligase B; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. | 0.770 |
| ACO80311.1 | bioB | Avin_41820 | Avin_05980 | Lysine 2,3-aminomutase. | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | 0.762 |
| ACO80311.1 | lipA | Avin_41820 | Avin_08460 | Lysine 2,3-aminomutase. | Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | 0.746 |
| bioB | ACO80311.1 | Avin_05980 | Avin_41820 | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | Lysine 2,3-aminomutase. | 0.762 |
| bioB | lipA | Avin_05980 | Avin_08460 | Biotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | 0.850 |
| erpA | lipA | Avin_46030 | Avin_08460 | Essential respiratory protein A, ErpA; Required for insertion of 4Fe-4S clusters for at least IspG. | Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | 0.684 |
| erpA | nfuA | Avin_46030 | Avin_28760 | Essential respiratory protein A, ErpA; Required for insertion of 4Fe-4S clusters for at least IspG. | NfuA protein; Involved in iron-sulfur cluster biogenesis. Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins. Could also act as a scaffold/chaperone for damaged Fe/S proteins. | 0.944 |
| gcvH | lipA | Avin_47270 | Avin_08460 | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Lipoic acid synthetase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | 0.948 |
| gcvH | lipB | Avin_47270 | Avin_08450 | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | Lipoate-protein ligase B; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. | 0.916 |
