node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACO77259.1 | ACO80915.1 | Avin_10270 | Avin_48110 | Short-chain dehydrogenase/reductase SDR. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.914 |
ACO77259.1 | folC | Avin_10270 | Avin_34180 | Short-chain dehydrogenase/reductase SDR. | Folylpolyglutamate synthetase protein; Belongs to the folylpolyglutamate synthase family. | 0.901 |
ACO77259.1 | glyA | Avin_10270 | Avin_40970 | Short-chain dehydrogenase/reductase SDR. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.910 |
ACO77259.1 | thyA | Avin_10270 | Avin_48170 | Short-chain dehydrogenase/reductase SDR. | Thymidylate synthase protein; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.903 |
ACO79566.1 | accD | Avin_34170 | Avin_34190 | Sporulation related repeat protein. | acetyl-CoA carboxylase, carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. | 0.769 |
ACO79566.1 | folC | Avin_34170 | Avin_34180 | Sporulation related repeat protein. | Folylpolyglutamate synthetase protein; Belongs to the folylpolyglutamate synthase family. | 0.895 |
ACO79566.1 | truA | Avin_34170 | Avin_34220 | Sporulation related repeat protein. | tRNA pseudouridine synthase A; Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs. | 0.405 |
ACO80915.1 | ACO77259.1 | Avin_48110 | Avin_10270 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Short-chain dehydrogenase/reductase SDR. | 0.914 |
ACO80915.1 | folC | Avin_48110 | Avin_34180 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Folylpolyglutamate synthetase protein; Belongs to the folylpolyglutamate synthase family. | 0.933 |
ACO80915.1 | folD | Avin_48110 | Avin_23540 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.410 |
ACO80915.1 | folP | Avin_48110 | Avin_42870 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. | 0.438 |
ACO80915.1 | glyA | Avin_48110 | Avin_40970 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.943 |
ACO80915.1 | guaA | Avin_48110 | Avin_39720 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.439 |
ACO80915.1 | thyA | Avin_48110 | Avin_48170 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Thymidylate synthase protein; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.998 |
accD | ACO79566.1 | Avin_34190 | Avin_34170 | acetyl-CoA carboxylase, carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. | Sporulation related repeat protein. | 0.769 |
accD | folC | Avin_34190 | Avin_34180 | acetyl-CoA carboxylase, carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. | Folylpolyglutamate synthetase protein; Belongs to the folylpolyglutamate synthase family. | 0.860 |
accD | truA | Avin_34190 | Avin_34220 | acetyl-CoA carboxylase, carboxyl transferase, beta subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. | tRNA pseudouridine synthase A; Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs. | 0.498 |
folC | ACO77259.1 | Avin_34180 | Avin_10270 | Folylpolyglutamate synthetase protein; Belongs to the folylpolyglutamate synthase family. | Short-chain dehydrogenase/reductase SDR. | 0.901 |
folC | ACO79566.1 | Avin_34180 | Avin_34170 | Folylpolyglutamate synthetase protein; Belongs to the folylpolyglutamate synthase family. | Sporulation related repeat protein. | 0.895 |
folC | ACO80915.1 | Avin_34180 | Avin_48110 | Folylpolyglutamate synthetase protein; Belongs to the folylpolyglutamate synthase family. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.933 |