Mhun_2637 protein (Methanospirillum hungatei)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

Mhun_2637

Putative PAS/PAC sensor protein. (461 aa)

Predicted Functional Partners:

Mhun_2636

0.934

Mhun_2687

0.731

Mhun_3038

0.730

Mhun_1723

0.729

Mhun_0454

0.720

Mhun_0463

0.706

Mhun_0640

0.702

Mhun_1618

0.651

Mhun_0107

0.650

Mhun_0110

0.612

Your Current Organism:

Methanospirillum hungatei

NCBI taxonomy Id: 323259
Other names: M. hungatei JF-1, Methanospirillum hungatei DSM 864, Methanospirillum hungatei JF-1, Methanospirillum hungatei NBRC 100397, Methanospirillum hungatei str. JF-1, Methanospirillum hungatei strain JF-1

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
Mhun_0107	Mhun_0110	Conserved hypothetical protein.	CheA signal transduction histidine kinases.	0.735
Mhun_0107	Mhun_2637	Conserved hypothetical protein.	Putative PAS/PAC sensor protein.	0.650
Mhun_0110	Mhun_0107	CheA signal transduction histidine kinases.	Conserved hypothetical protein.	0.735
Mhun_0110	Mhun_2637	CheA signal transduction histidine kinases.	Putative PAS/PAC sensor protein.	0.612
Mhun_0454	Mhun_1618	Signal transduction histidine kinase.	Response regulator receiver domain protein (CheY-like).	0.400
Mhun_0454	Mhun_2637	Signal transduction histidine kinase.	Putative PAS/PAC sensor protein.	0.720
Mhun_0463	Mhun_2637	Putative signal transduction histidine kinase.	Putative PAS/PAC sensor protein.	0.706
Mhun_0463	Mhun_3038	Putative signal transduction histidine kinase.	Signal transduction histidine kinase.	0.695
Mhun_0640	Mhun_1618	Multi-sensor signal transduction histidine kinase.	Response regulator receiver domain protein (CheY-like).	0.569
Mhun_0640	Mhun_2637	Multi-sensor signal transduction histidine kinase.	Putative PAS/PAC sensor protein.	0.702
Mhun_1618	Mhun_0454	Response regulator receiver domain protein (CheY-like).	Signal transduction histidine kinase.	0.400
Mhun_1618	Mhun_0640	Response regulator receiver domain protein (CheY-like).	Multi-sensor signal transduction histidine kinase.	0.569
Mhun_1618	Mhun_2637	Response regulator receiver domain protein (CheY-like).	Putative PAS/PAC sensor protein.	0.651
Mhun_1723	Mhun_2637	Signal transduction histidine kinase.	Putative PAS/PAC sensor protein.	0.729
Mhun_2636	Mhun_2637	Signal transduction histidine kinase.	Putative PAS/PAC sensor protein.	0.934
Mhun_2637	Mhun_0107	Putative PAS/PAC sensor protein.	Conserved hypothetical protein.	0.650
Mhun_2637	Mhun_0110	Putative PAS/PAC sensor protein.	CheA signal transduction histidine kinases.	0.612
Mhun_2637	Mhun_0454	Putative PAS/PAC sensor protein.	Signal transduction histidine kinase.	0.720
Mhun_2637	Mhun_0463	Putative PAS/PAC sensor protein.	Putative signal transduction histidine kinase.	0.706
Mhun_2637	Mhun_0640	Putative PAS/PAC sensor protein.	Multi-sensor signal transduction histidine kinase.	0.702

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

44

average node degree:

8

avg. local clustering coefficient:

0.843

expected number of edges:

15

PPI enrichment p-value:

5.57e-10

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0042351

De novo GDP-L-fucose biosynthetic process

4 of 5

3.5

4.94

1.19e-09

GO:0009226

Nucleotide-sugar biosynthetic process

5 of 44

2.65

4.68

1.19e-09

GO:1901137

Carbohydrate derivative biosynthetic process

7 of 518

1.73

3.04

6.86e-09

GO:0018130

Heterocycle biosynthetic process

7 of 983

1.45

2.04

4.44e-07

GO:0030656

Regulation of vitamin metabolic process

2 of 6

3.12

1.86

0.00044

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0050577

GDP-L-fucose synthase activity

3 of 3

3.6

3.66

2.56e-07

GO:0016853

Isomerase activity

6 of 321

1.87

2.92

1.62e-07

GO:0047918

GDP-mannose 3,5-epimerase activity

2 of 2

3.6

2.0

0.00025

GO:0003824

Catalytic activity

11 of 12906

0.53

0.43

0.00081

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:37836106

(2023) Genome and Transcriptome Analyses of Genes Involved in Ascorbate Biosynthesis in Pepper Indicate Key Genes Related to Fruit Development, Stresses, and Phytohormone Exposures.

2 of 5

3.2

0.9

0.0243

PMID:34179502

(2021) In silico analysis of glycosyltransferase 2 family genes in duckweed (Spirodela polyrhiza) and its role in salt stress tolerance.

2 of 3

3.42

0.9

0.0243

PMID:33328457

(2020) A CCAAT-binding factor, SlNFYA10, negatively regulates ascorbate accumulation by modulating the D-mannoseL-galactose pathway in tomato.

2 of 5

3.2

0.9

0.0243

PMID:32252624

(2020) Genome-wide analysis of Myo-inositol oxygenase gene family in tomato reveals their involvement in ascorbic acid accumulation.

2 of 5

3.2

0.9

0.0243

PMID:25023870

(2014) Annotation of gene function in citrus using gene expression information and co-expression networks.

2 of 3

3.42

0.9

0.0243

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:33170

De novo GDP-L-fucose biosynthetic process, and MobA-like NTP transferase domain

7 of 12

3.36

9.71

1.45e-18

CL:33172

MobA-like NTP transferase domain, and GDP-mannose 3,5-epimerase

3 of 7

3.23

3.26

1.25e-06

CL:33716

Dolichol-phosphate-mannose synthase complex, and alpha-1,3-mannosyltransferase activity

2 of 5

3.2

1.69

0.00091

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00520

Amino sugar and nucleotide sugar metabolism

9 of 297

2.08

6.09

3.02e-16

map00051

Fructose and mannose metabolism

6 of 137

2.24

4.86

3.89e-11

map00510

N-Glycan biosynthesis

2 of 76

2.02

1.14

0.0066

map00053

Ascorbate and aldarate metabolism

2 of 99

1.9

1.06

0.0088

map01100

Metabolic pathways

11 of 6275

0.84

0.92

2.79e-08

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-446219

Synthesis of substrates in N-glycan biosythesis

9 of 58

2.79

10.51

1.20e-21

MAP-446193

Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein

9 of 87

2.61

9.52

1.82e-20

MAP-446203

Asparagine N-linked glycosylation

9 of 344

2.02

5.61

1.96e-15

MAP-6787639

GDP-fucose biosynthesis

4 of 6

3.42

5.53

9.31e-11

MAP-597592

Post-translational protein modification

9 of 1407

1.4

2.38

3.26e-10

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005829

Cytosol

5 of 1060

1.27

0.93

0.0046

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0413

Isomerase

5 of 144

2.14

3.39

7.94e-08

KW-0060

Ascorbate biosynthesis

2 of 3

3.42

2.18

0.00012

KW-0511

Multifunctional enzyme

2 of 22

2.56

1.46

0.0021

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR001509

NAD-dependent epimerase/dehydratase

4 of 54

2.47

2.78

5.35e-06

IPR029044

Nucleotide-diphospho-sugar transferases

4 of 152

2.02

1.99

9.85e-05

IPR033890

GDP-mannose 3,5-epimerase

2 of 2

3.6

1.84

0.00050

IPR028614

GDP-L-fucose synthase/GDP-L-colitose synthase

2 of 2

3.6

1.84

0.00050

IPR036291

NAD(P)-binding domain superfamily

5 of 394

1.7

1.81

7.99e-05

(more ...)

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (16%) [HD]

Permalink

Network

Neighborhood

Experiments

Fusion

Textmining

Cooccurrence

Databases

Coexpression

© STRING Consortium 2024

Credits

Access

Info

About