node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Noc_1266 | Noc_2519 | Noc_1266 | Noc_2519 | Acetolactate synthase large subunit; Belongs to the TPP enzyme family. | Acetolactate synthase, small subunit. | 0.998 |
Noc_1266 | Noc_2520 | Noc_1266 | Noc_2520 | Acetolactate synthase large subunit; Belongs to the TPP enzyme family. | Acetolactate synthase, large subunit. | 0.927 |
Noc_1266 | ilvA | Noc_1266 | Noc_2666 | Acetolactate synthase large subunit; Belongs to the TPP enzyme family. | L-threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.933 |
Noc_1266 | ilvC | Noc_1266 | Noc_2518 | Acetolactate synthase large subunit; Belongs to the TPP enzyme family. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.992 |
Noc_1266 | ilvD | Noc_1266 | Noc_2001 | Acetolactate synthase large subunit; Belongs to the TPP enzyme family. | Dihydroxyacid dehydratase; Belongs to the IlvD/Edd family. | 0.821 |
Noc_1266 | leuA | Noc_1266 | Noc_2516 | Acetolactate synthase large subunit; Belongs to the TPP enzyme family. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.907 |
Noc_1266 | leuB | Noc_1266 | Noc_1014 | Acetolactate synthase large subunit; Belongs to the TPP enzyme family. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily. | 0.951 |
Noc_1266 | leuD | Noc_1266 | Noc_1013 | Acetolactate synthase large subunit; Belongs to the TPP enzyme family. | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.493 |
Noc_2519 | Noc_1266 | Noc_2519 | Noc_1266 | Acetolactate synthase, small subunit. | Acetolactate synthase large subunit; Belongs to the TPP enzyme family. | 0.998 |
Noc_2519 | Noc_2520 | Noc_2519 | Noc_2520 | Acetolactate synthase, small subunit. | Acetolactate synthase, large subunit. | 0.999 |
Noc_2519 | ilvA | Noc_2519 | Noc_2666 | Acetolactate synthase, small subunit. | L-threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.988 |
Noc_2519 | ilvC | Noc_2519 | Noc_2518 | Acetolactate synthase, small subunit. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.999 |
Noc_2519 | ilvD | Noc_2519 | Noc_2001 | Acetolactate synthase, small subunit. | Dihydroxyacid dehydratase; Belongs to the IlvD/Edd family. | 0.917 |
Noc_2519 | leuA | Noc_2519 | Noc_2516 | Acetolactate synthase, small subunit. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.978 |
Noc_2519 | leuB | Noc_2519 | Noc_1014 | Acetolactate synthase, small subunit. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily. | 0.992 |
Noc_2519 | leuC | Noc_2519 | Noc_2935 | Acetolactate synthase, small subunit. | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.908 |
Noc_2519 | leuD | Noc_2519 | Noc_1013 | Acetolactate synthase, small subunit. | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.907 |
Noc_2520 | Noc_1266 | Noc_2520 | Noc_1266 | Acetolactate synthase, large subunit. | Acetolactate synthase large subunit; Belongs to the TPP enzyme family. | 0.927 |
Noc_2520 | Noc_2519 | Noc_2520 | Noc_2519 | Acetolactate synthase, large subunit. | Acetolactate synthase, small subunit. | 0.999 |
Noc_2520 | ilvA | Noc_2520 | Noc_2666 | Acetolactate synthase, large subunit. | L-threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.933 |