| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Noc_2017 | hisA | Noc_2017 | Noc_3053 | HAD-superfamily subfamily IB, PSPase-like protein. | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | 0.735 |
| Noc_2017 | hisB | Noc_2017 | Noc_3051 | HAD-superfamily subfamily IB, PSPase-like protein. | Imidazoleglycerol-phosphate dehydratase. | 0.720 |
| Noc_2017 | hisC1 | Noc_2017 | Noc_0175 | HAD-superfamily subfamily IB, PSPase-like protein. | Aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.575 |
| Noc_2017 | hisC2 | Noc_2017 | Noc_2777 | HAD-superfamily subfamily IB, PSPase-like protein. | Histidinol phosphate aminotransferase apoenzyme; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.575 |
| Noc_2017 | hisD | Noc_2017 | Noc_2778 | HAD-superfamily subfamily IB, PSPase-like protein. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.664 |
| Noc_2017 | hisE | Noc_2017 | Noc_3056 | HAD-superfamily subfamily IB, PSPase-like protein. | phosphoribosyl-ATP pyrophosphatase. | 0.600 |
| Noc_2017 | hisF | Noc_2017 | Noc_3054 | HAD-superfamily subfamily IB, PSPase-like protein. | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.785 |
| Noc_2017 | hisH | Noc_2017 | Noc_3052 | HAD-superfamily subfamily IB, PSPase-like protein. | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.756 |
| Noc_2017 | hisI | Noc_2017 | Noc_3055 | HAD-superfamily subfamily IB, PSPase-like protein. | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.726 |
| Noc_2017 | hisZ | Noc_2017 | Noc_2586 | HAD-superfamily subfamily IB, PSPase-like protein. | tRNA synthetase, class II (G, H, P and S); Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. | 0.848 |
| hisA | Noc_2017 | Noc_3053 | Noc_2017 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | HAD-superfamily subfamily IB, PSPase-like protein. | 0.735 |
| hisA | hisB | Noc_3053 | Noc_3051 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | Imidazoleglycerol-phosphate dehydratase. | 0.993 |
| hisA | hisC1 | Noc_3053 | Noc_0175 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | Aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.896 |
| hisA | hisC2 | Noc_3053 | Noc_2777 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | Histidinol phosphate aminotransferase apoenzyme; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.929 |
| hisA | hisD | Noc_3053 | Noc_2778 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.989 |
| hisA | hisE | Noc_3053 | Noc_3056 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | phosphoribosyl-ATP pyrophosphatase. | 0.995 |
| hisA | hisF | Noc_3053 | Noc_3054 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | Imidazole glycerol phosphate synthase subunit hisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.999 |
| hisA | hisH | Noc_3053 | Noc_3052 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | Imidazole glycerol phosphate synthase subunit hisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.999 |
| hisA | hisI | Noc_3053 | Noc_3055 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.999 |
| hisA | hisZ | Noc_3053 | Noc_2586 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | tRNA synthetase, class II (G, H, P and S); Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. | 0.924 |