node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABB73636.1 | ABB74859.1 | Nmul_A0328 | Nmul_A1556 | Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s). | Multi-sensor hybrid histidine kinase. | 0.996 |
ABB73636.1 | ABB74938.1 | Nmul_A0328 | Nmul_A1638 | Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s). | Nitrogen regulatory protein P-II (GlnB, GlnK). | 0.557 |
ABB73636.1 | ABB75580.1 | Nmul_A0328 | Nmul_A2288 | Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s). | L-glutamine synthetase. | 0.540 |
ABB73636.1 | argA | Nmul_A0328 | Nmul_A0380 | Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s). | N-acetylglutamate synthase; Belongs to the acetyltransferase family. ArgA subfamily. | 0.449 |
ABB73636.1 | glnD | Nmul_A0328 | Nmul_A2633 | Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s). | UTP-GlnB (protein PII) uridylyltransferase, GlnD; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism. | 0.469 |
ABB73636.1 | glnE | Nmul_A0328 | Nmul_A1058 | Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s). | Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] | 0.458 |
ABB73636.1 | nadE | Nmul_A0328 | Nmul_A2535 | Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s). | NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.493 |
ABB74360.1 | glnE | Nmul_A1057 | Nmul_A1058 | Conserved hypothetical protein. | Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] | 0.497 |
ABB74362.1 | glnE | Nmul_A1059 | Nmul_A1058 | Conserved hypothetical protein. | Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] | 0.430 |
ABB74696.1 | argA | Nmul_A1393 | Nmul_A0380 | ATP-dependent helicase HrpA. | N-acetylglutamate synthase; Belongs to the acetyltransferase family. ArgA subfamily. | 0.456 |
ABB74696.1 | glnE | Nmul_A1393 | Nmul_A1058 | ATP-dependent helicase HrpA. | Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] | 0.588 |
ABB74859.1 | ABB73636.1 | Nmul_A1556 | Nmul_A0328 | Multi-sensor hybrid histidine kinase. | Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s). | 0.996 |
ABB74859.1 | ABB75580.1 | Nmul_A1556 | Nmul_A2288 | Multi-sensor hybrid histidine kinase. | L-glutamine synthetase. | 0.540 |
ABB74859.1 | glnE | Nmul_A1556 | Nmul_A1058 | Multi-sensor hybrid histidine kinase. | Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] | 0.468 |
ABB74859.1 | nadE | Nmul_A1556 | Nmul_A2535 | Multi-sensor hybrid histidine kinase. | NAD+ synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. | 0.686 |
ABB74938.1 | ABB73636.1 | Nmul_A1638 | Nmul_A0328 | Nitrogen regulatory protein P-II (GlnB, GlnK). | Diguanylate cyclase/phosphodiesterase with PAS/PAC sensor(s). | 0.557 |
ABB74938.1 | ABB75580.1 | Nmul_A1638 | Nmul_A2288 | Nitrogen regulatory protein P-II (GlnB, GlnK). | L-glutamine synthetase. | 0.504 |
ABB74938.1 | argA | Nmul_A1638 | Nmul_A0380 | Nitrogen regulatory protein P-II (GlnB, GlnK). | N-acetylglutamate synthase; Belongs to the acetyltransferase family. ArgA subfamily. | 0.822 |
ABB74938.1 | glnD | Nmul_A1638 | Nmul_A2633 | Nitrogen regulatory protein P-II (GlnB, GlnK). | UTP-GlnB (protein PII) uridylyltransferase, GlnD; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism. | 0.988 |
ABB74938.1 | glnE | Nmul_A1638 | Nmul_A1058 | Nitrogen regulatory protein P-II (GlnB, GlnK). | Glutamate-ammonia-ligase adenylyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transd [...] | 0.570 |