STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Shew_1764PFAM: nickel-dependent hydrogenase, large subunit; KEGG: she:Shewmr4_1821 nickel-dependent hydrogenase, large subunit; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. (568 aa)    
Predicted Functional Partners:
Shew_1765
KEGG: shm:Shewmr7_2155 hydrogenase (NiFe) small subunit HydA; TIGRFAM: hydrogenase (NiFe) small subunit HydA; PFAM: NADH ubiquinone oxidoreductase, 20 kDa subunit; Nickel-iron dehydrogenase small subunit, N-terminal domain protein.
 
 
 0.999
Shew_1763
TIGRFAM: Ni/Fe-hydrogenase, b-type cytochrome subunit; PFAM: cytochrome B561; KEGG: she:Shewmr4_1820 Ni/Fe-hydrogenase, b-type cytochrome subunit.
 
 
 0.998
hypA
Hydrogenase expression/synthesis, HypA; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.
 
 
 0.983
Shew_1762
TIGRFAM: hydrogenase maturation protease; hydrogenase expression/formation protein; PFAM: peptidase M52, hydrogen uptake protein; KEGG: shm:Shewmr7_2158 hydrogenase expression/formation protein.
 
 
 0.979
Shew_1760
(NiFe) hydrogenase maturation protein HypF; Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide.
 
 
 
 0.952
Shew_1757
TIGRFAM: hydrogenase expression/formation protein HypD; PFAM: hydrogenase formation HypD protein; KEGG: shm:Shewmr7_2163 hydrogenase expression/formation protein HypD; Belongs to the HypD family.
 
 
 0.937
Shew_1758
TIGRFAM: hydrogenase assembly chaperone hypC/hupF; PFAM: hydrogenase expression/formation protein (HUPF/HYPC); KEGG: son:SO2092 hydrogenase assembly chaperone hypC/hupF.
 
 
 0.915
Shew_1759
TIGRFAM: hydrogenase accessory protein HypB; PFAM: cobalamin synthesis protein, P47K; KEGG: she:Shewmr4_1816 hydrogenase accessory protein HypB.
 
   
 0.914
Shew_1756
TIGRFAM: hydrogenase expression/formation protein HypE; PFAM: AIR synthase related protein; AIR synthase related protein domain protein; KEGG: sfr:Sfri_2112 hydrogenase expression/formation protein HypE.
 
   
 0.913
Shew_1761
KEGG: she:Shewmr4_1818 hypothetical protein.
   
 
 0.821
Your Current Organism:
Shewanella loihica
NCBI taxonomy Id: 323850
Other names: S. loihica PV-4, Shewanella loihica PV-4, Shewanella loihica str. PV-4, Shewanella loihica strain PV-4, Shewanella sp. PV-4
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