| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Shew_0294 | Shew_1965 | Shew_0294 | Shew_1965 | PFAM: aminotransferase, class V; KEGG: son:SO4343 aminotransferase, class V. | PFAM: phospholipase D/Transphosphatidylase; KEGG: she:Shewmr4_1935 phospholipase D/transphosphatidylase. | 0.900 |
| Shew_0294 | Shew_2945 | Shew_0294 | Shew_2945 | PFAM: aminotransferase, class V; KEGG: son:SO4343 aminotransferase, class V. | KEGG: shm:Shewmr7_3070 CDP-diacylglycerol--serine O-phosphatidyltransferase; TIGRFAM: CDP-diacylglycerol--serine O-phosphatidyltransferase; PFAM: CDP-alcohol phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | 0.900 |
| Shew_0294 | glyA | Shew_0294 | Shew_1185 | PFAM: aminotransferase, class V; KEGG: son:SO4343 aminotransferase, class V. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.927 |
| Shew_0294 | ilvA | Shew_0294 | Shew_0293 | PFAM: aminotransferase, class V; KEGG: son:SO4343 aminotransferase, class V. | L-threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.947 |
| Shew_0294 | trpA | Shew_0294 | Shew_2256 | PFAM: aminotransferase, class V; KEGG: son:SO4343 aminotransferase, class V. | Tryptophan synthase, alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.912 |
| Shew_0294 | trpB | Shew_0294 | Shew_2255 | PFAM: aminotransferase, class V; KEGG: son:SO4343 aminotransferase, class V. | Tryptophan synthase, beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.908 |
| Shew_0671 | Shew_1965 | Shew_0671 | Shew_1965 | Phospholipase A(1); Hydrolysis of phosphatidylcholine with phospholipase A2 (EC 3.1.1.4) and phospholipase A1 (EC 3.1.1.32) activities. Belongs to the phospholipase A1 family. | PFAM: phospholipase D/Transphosphatidylase; KEGG: she:Shewmr4_1935 phospholipase D/transphosphatidylase. | 0.906 |
| Shew_0671 | Shew_2945 | Shew_0671 | Shew_2945 | Phospholipase A(1); Hydrolysis of phosphatidylcholine with phospholipase A2 (EC 3.1.1.4) and phospholipase A1 (EC 3.1.1.32) activities. Belongs to the phospholipase A1 family. | KEGG: shm:Shewmr7_3070 CDP-diacylglycerol--serine O-phosphatidyltransferase; TIGRFAM: CDP-diacylglycerol--serine O-phosphatidyltransferase; PFAM: CDP-alcohol phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | 0.900 |
| Shew_0671 | psd | Shew_0671 | Shew_0557 | Phospholipase A(1); Hydrolysis of phosphatidylcholine with phospholipase A2 (EC 3.1.1.4) and phospholipase A1 (EC 3.1.1.32) activities. Belongs to the phospholipase A1 family. | Phosphatidylserine decarboxylase; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). | 0.900 |
| Shew_1826 | Shew_1965 | Shew_1826 | Shew_1965 | KEGG: shm:Shewmr7_1616 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; TIGRFAM: CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; PFAM: CDP-alcohol phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | PFAM: phospholipase D/Transphosphatidylase; KEGG: she:Shewmr4_1935 phospholipase D/transphosphatidylase. | 0.940 |
| Shew_1826 | Shew_2630 | Shew_1826 | Shew_2630 | KEGG: shm:Shewmr7_1616 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; TIGRFAM: CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; PFAM: CDP-alcohol phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | PFAM: phosphatidate cytidylyltransferase; KEGG: shm:Shewmr7_2703 phosphatidate cytidylyltransferase; Belongs to the CDS family. | 0.957 |
| Shew_1826 | Shew_2945 | Shew_1826 | Shew_2945 | KEGG: shm:Shewmr7_1616 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; TIGRFAM: CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; PFAM: CDP-alcohol phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | KEGG: shm:Shewmr7_3070 CDP-diacylglycerol--serine O-phosphatidyltransferase; TIGRFAM: CDP-diacylglycerol--serine O-phosphatidyltransferase; PFAM: CDP-alcohol phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | 0.931 |
| Shew_1826 | psd | Shew_1826 | Shew_0557 | KEGG: shm:Shewmr7_1616 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; TIGRFAM: CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; PFAM: CDP-alcohol phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | Phosphatidylserine decarboxylase; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). | 0.856 |
| Shew_1965 | Shew_0294 | Shew_1965 | Shew_0294 | PFAM: phospholipase D/Transphosphatidylase; KEGG: she:Shewmr4_1935 phospholipase D/transphosphatidylase. | PFAM: aminotransferase, class V; KEGG: son:SO4343 aminotransferase, class V. | 0.900 |
| Shew_1965 | Shew_0671 | Shew_1965 | Shew_0671 | PFAM: phospholipase D/Transphosphatidylase; KEGG: she:Shewmr4_1935 phospholipase D/transphosphatidylase. | Phospholipase A(1); Hydrolysis of phosphatidylcholine with phospholipase A2 (EC 3.1.1.4) and phospholipase A1 (EC 3.1.1.32) activities. Belongs to the phospholipase A1 family. | 0.906 |
| Shew_1965 | Shew_1826 | Shew_1965 | Shew_1826 | PFAM: phospholipase D/Transphosphatidylase; KEGG: she:Shewmr4_1935 phospholipase D/transphosphatidylase. | KEGG: shm:Shewmr7_1616 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; TIGRFAM: CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; PFAM: CDP-alcohol phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | 0.940 |
| Shew_1965 | Shew_2630 | Shew_1965 | Shew_2630 | PFAM: phospholipase D/Transphosphatidylase; KEGG: she:Shewmr4_1935 phospholipase D/transphosphatidylase. | PFAM: phosphatidate cytidylyltransferase; KEGG: shm:Shewmr7_2703 phosphatidate cytidylyltransferase; Belongs to the CDS family. | 0.936 |
| Shew_1965 | Shew_2945 | Shew_1965 | Shew_2945 | PFAM: phospholipase D/Transphosphatidylase; KEGG: she:Shewmr4_1935 phospholipase D/transphosphatidylase. | KEGG: shm:Shewmr7_3070 CDP-diacylglycerol--serine O-phosphatidyltransferase; TIGRFAM: CDP-diacylglycerol--serine O-phosphatidyltransferase; PFAM: CDP-alcohol phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. | 0.907 |
| Shew_1965 | glyA | Shew_1965 | Shew_1185 | PFAM: phospholipase D/Transphosphatidylase; KEGG: she:Shewmr4_1935 phospholipase D/transphosphatidylase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.932 |
| Shew_1965 | ilvA | Shew_1965 | Shew_0293 | PFAM: phospholipase D/Transphosphatidylase; KEGG: she:Shewmr4_1935 phospholipase D/transphosphatidylase. | L-threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.901 |