| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Shew_0540 | Shew_3218 | Shew_0540 | Shew_3218 | PFAM: Enoyl-CoA hydratase/isomerase; KEGG: shm:Shewmr7_0749 enoyl-CoA hydratase/isomerase. | PFAM: biotin/lipoyl attachment domain-containing protein; Carbamoyl-phosphate synthase L chain, ATP-binding; Carbamoyl-phosphate synthetase large chain domain protein; biotin carboxylase domain protein; KEGG: she:Shewmr4_0696 carbamoyl-phosphate synthase L chain, ATP-binding. | 0.789 |
| Shew_0540 | Shew_3602 | Shew_0540 | Shew_3602 | PFAM: Enoyl-CoA hydratase/isomerase; KEGG: shm:Shewmr7_0749 enoyl-CoA hydratase/isomerase. | TIGRFAM: O-succinylbenzoate-CoA ligase; PFAM: AMP-dependent synthetase and ligase; KEGG: she:Shewmr4_3770 O-succinylbenzoate-CoA ligase. | 0.562 |
| Shew_0540 | menD | Shew_0540 | Shew_3599 | PFAM: Enoyl-CoA hydratase/isomerase; KEGG: shm:Shewmr7_0749 enoyl-CoA hydratase/isomerase. | 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2- succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC). | 0.448 |
| Shew_2665 | Shew_3218 | Shew_2665 | Shew_3218 | PFAM: beta-ketoacyl synthase; acyl transferase domain protein; short-chain dehydrogenase/reductase SDR; KR; KEGG: ppr:PBPRA1460 omega-3 polyunsaturated fatty acid synthase PfaA. | PFAM: biotin/lipoyl attachment domain-containing protein; Carbamoyl-phosphate synthase L chain, ATP-binding; Carbamoyl-phosphate synthetase large chain domain protein; biotin carboxylase domain protein; KEGG: she:Shewmr4_0696 carbamoyl-phosphate synthase L chain, ATP-binding. | 0.889 |
| Shew_2665 | Shew_3602 | Shew_2665 | Shew_3602 | PFAM: beta-ketoacyl synthase; acyl transferase domain protein; short-chain dehydrogenase/reductase SDR; KR; KEGG: ppr:PBPRA1460 omega-3 polyunsaturated fatty acid synthase PfaA. | TIGRFAM: O-succinylbenzoate-CoA ligase; PFAM: AMP-dependent synthetase and ligase; KEGG: she:Shewmr4_3770 O-succinylbenzoate-CoA ligase. | 0.854 |
| Shew_2665 | menF | Shew_2665 | Shew_3677 | PFAM: beta-ketoacyl synthase; acyl transferase domain protein; short-chain dehydrogenase/reductase SDR; KR; KEGG: ppr:PBPRA1460 omega-3 polyunsaturated fatty acid synthase PfaA. | Isochorismate synthase; Catalyzes the conversion of chorismate to isochorismate. | 0.721 |
| Shew_3218 | Shew_0540 | Shew_3218 | Shew_0540 | PFAM: biotin/lipoyl attachment domain-containing protein; Carbamoyl-phosphate synthase L chain, ATP-binding; Carbamoyl-phosphate synthetase large chain domain protein; biotin carboxylase domain protein; KEGG: she:Shewmr4_0696 carbamoyl-phosphate synthase L chain, ATP-binding. | PFAM: Enoyl-CoA hydratase/isomerase; KEGG: shm:Shewmr7_0749 enoyl-CoA hydratase/isomerase. | 0.789 |
| Shew_3218 | Shew_2665 | Shew_3218 | Shew_2665 | PFAM: biotin/lipoyl attachment domain-containing protein; Carbamoyl-phosphate synthase L chain, ATP-binding; Carbamoyl-phosphate synthetase large chain domain protein; biotin carboxylase domain protein; KEGG: she:Shewmr4_0696 carbamoyl-phosphate synthase L chain, ATP-binding. | PFAM: beta-ketoacyl synthase; acyl transferase domain protein; short-chain dehydrogenase/reductase SDR; KR; KEGG: ppr:PBPRA1460 omega-3 polyunsaturated fatty acid synthase PfaA. | 0.889 |
| Shew_3218 | Shew_3602 | Shew_3218 | Shew_3602 | PFAM: biotin/lipoyl attachment domain-containing protein; Carbamoyl-phosphate synthase L chain, ATP-binding; Carbamoyl-phosphate synthetase large chain domain protein; biotin carboxylase domain protein; KEGG: she:Shewmr4_0696 carbamoyl-phosphate synthase L chain, ATP-binding. | TIGRFAM: O-succinylbenzoate-CoA ligase; PFAM: AMP-dependent synthetase and ligase; KEGG: she:Shewmr4_3770 O-succinylbenzoate-CoA ligase. | 0.580 |
| Shew_3598 | Shew_3601 | Shew_3598 | Shew_3601 | PFAM: regulatory protein, AsnC/Lrp family; regulatory protein, ArsR; KEGG: shm:Shewmr7_3834 transcriptional regulator, AsnC family. | KEGG: shm:Shewmr7_3842 O-succinylbenzoate-CoA synthase. | 0.526 |
| Shew_3598 | Shew_3602 | Shew_3598 | Shew_3602 | PFAM: regulatory protein, AsnC/Lrp family; regulatory protein, ArsR; KEGG: shm:Shewmr7_3834 transcriptional regulator, AsnC family. | TIGRFAM: O-succinylbenzoate-CoA ligase; PFAM: AMP-dependent synthetase and ligase; KEGG: she:Shewmr4_3770 O-succinylbenzoate-CoA ligase. | 0.526 |
| Shew_3598 | menD | Shew_3598 | Shew_3599 | PFAM: regulatory protein, AsnC/Lrp family; regulatory protein, ArsR; KEGG: shm:Shewmr7_3834 transcriptional regulator, AsnC family. | 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2- succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC). | 0.526 |
| Shew_3598 | menH | Shew_3598 | Shew_3600 | PFAM: regulatory protein, AsnC/Lrp family; regulatory protein, ArsR; KEGG: shm:Shewmr7_3834 transcriptional regulator, AsnC family. | Alpha/beta hydrolase fold; Catalyzes a proton abstraction reaction that results in 2,5- elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6- hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). | 0.535 |
| Shew_3601 | Shew_3598 | Shew_3601 | Shew_3598 | KEGG: shm:Shewmr7_3842 O-succinylbenzoate-CoA synthase. | PFAM: regulatory protein, AsnC/Lrp family; regulatory protein, ArsR; KEGG: shm:Shewmr7_3834 transcriptional regulator, AsnC family. | 0.526 |
| Shew_3601 | Shew_3602 | Shew_3601 | Shew_3602 | KEGG: shm:Shewmr7_3842 O-succinylbenzoate-CoA synthase. | TIGRFAM: O-succinylbenzoate-CoA ligase; PFAM: AMP-dependent synthetase and ligase; KEGG: she:Shewmr4_3770 O-succinylbenzoate-CoA ligase. | 0.990 |
| Shew_3601 | menA | Shew_3601 | Shew_2558 | KEGG: shm:Shewmr7_3842 O-succinylbenzoate-CoA synthase. | 1,4-Dihydroxy-2-naphtoate prenyltransferase; Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK); Belongs to the MenA family. Type 1 subfamily. | 0.708 |
| Shew_3601 | menB | Shew_3601 | Shew_3814 | KEGG: shm:Shewmr7_3842 O-succinylbenzoate-CoA synthase. | 1,4-Dihydroxy-2-naphthoate synthase; Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2- naphthoyl-CoA (DHNA-CoA); Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily. | 0.917 |
| Shew_3601 | menD | Shew_3601 | Shew_3599 | KEGG: shm:Shewmr7_3842 O-succinylbenzoate-CoA synthase. | 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2- succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC). | 0.953 |
| Shew_3601 | menF | Shew_3601 | Shew_3677 | KEGG: shm:Shewmr7_3842 O-succinylbenzoate-CoA synthase. | Isochorismate synthase; Catalyzes the conversion of chorismate to isochorismate. | 0.692 |
| Shew_3601 | menH | Shew_3601 | Shew_3600 | KEGG: shm:Shewmr7_3842 O-succinylbenzoate-CoA synthase. | Alpha/beta hydrolase fold; Catalyzes a proton abstraction reaction that results in 2,5- elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6- hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). | 0.992 |