node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Caur_0164 | Caur_0328 | Caur_0164 | Caur_0328 | TIGRFAM: acetolactate synthase, small subunit; PFAM: amino acid-binding ACT domain protein; KEGG: rrs:RoseRS_1967 acetolactate synthase, small subunit. | PFAM: pyruvate carboxyltransferase; KEGG: afw:Anae109_2393 homocitrate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.749 |
Caur_0164 | Caur_0331 | Caur_0164 | Caur_0331 | TIGRFAM: acetolactate synthase, small subunit; PFAM: amino acid-binding ACT domain protein; KEGG: rrs:RoseRS_1967 acetolactate synthase, small subunit. | PFAM: isocitrate/isopropylmalate dehydrogenase; KEGG: rrs:RoseRS_1057 3-isopropylmalate dehydrogenase. | 0.840 |
Caur_0164 | ilvC | Caur_0164 | Caur_0165 | TIGRFAM: acetolactate synthase, small subunit; PFAM: amino acid-binding ACT domain protein; KEGG: rrs:RoseRS_1967 acetolactate synthase, small subunit. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.999 |
Caur_0164 | ilvD | Caur_0164 | Caur_2851 | TIGRFAM: acetolactate synthase, small subunit; PFAM: amino acid-binding ACT domain protein; KEGG: rrs:RoseRS_1967 acetolactate synthase, small subunit. | KEGG: tel:tll1057 dihydroxyacid dehydratase; TIGRFAM: dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. | 0.949 |
Caur_0164 | leuA | Caur_0164 | Caur_0166 | TIGRFAM: acetolactate synthase, small subunit; PFAM: amino acid-binding ACT domain protein; KEGG: rrs:RoseRS_1967 acetolactate synthase, small subunit. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.976 |
Caur_0164 | leuC | Caur_0164 | Caur_0168 | TIGRFAM: acetolactate synthase, small subunit; PFAM: amino acid-binding ACT domain protein; KEGG: rrs:RoseRS_1967 acetolactate synthase, small subunit. | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.872 |
Caur_0164 | leuC-2 | Caur_0164 | Caur_0329 | TIGRFAM: acetolactate synthase, small subunit; PFAM: amino acid-binding ACT domain protein; KEGG: rrs:RoseRS_1967 acetolactate synthase, small subunit. | 3-isopropylmalate dehydratase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.884 |
Caur_0164 | leuD | Caur_0164 | Caur_0169 | TIGRFAM: acetolactate synthase, small subunit; PFAM: amino acid-binding ACT domain protein; KEGG: rrs:RoseRS_1967 acetolactate synthase, small subunit. | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.888 |
Caur_0164 | leuD-2 | Caur_0164 | Caur_0330 | TIGRFAM: acetolactate synthase, small subunit; PFAM: amino acid-binding ACT domain protein; KEGG: rrs:RoseRS_1967 acetolactate synthase, small subunit. | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. | 0.902 |
Caur_0328 | Caur_0164 | Caur_0328 | Caur_0164 | PFAM: pyruvate carboxyltransferase; KEGG: afw:Anae109_2393 homocitrate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | TIGRFAM: acetolactate synthase, small subunit; PFAM: amino acid-binding ACT domain protein; KEGG: rrs:RoseRS_1967 acetolactate synthase, small subunit. | 0.749 |
Caur_0328 | Caur_0331 | Caur_0328 | Caur_0331 | PFAM: pyruvate carboxyltransferase; KEGG: afw:Anae109_2393 homocitrate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | PFAM: isocitrate/isopropylmalate dehydrogenase; KEGG: rrs:RoseRS_1057 3-isopropylmalate dehydrogenase. | 0.945 |
Caur_0328 | ilvC | Caur_0328 | Caur_0165 | PFAM: pyruvate carboxyltransferase; KEGG: afw:Anae109_2393 homocitrate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.821 |
Caur_0328 | ilvD | Caur_0328 | Caur_2851 | PFAM: pyruvate carboxyltransferase; KEGG: afw:Anae109_2393 homocitrate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | KEGG: tel:tll1057 dihydroxyacid dehydratase; TIGRFAM: dihydroxy-acid dehydratase; PFAM: dihydroxy-acid and 6-phosphogluconate dehydratase; Belongs to the IlvD/Edd family. | 0.812 |
Caur_0328 | leuA | Caur_0328 | Caur_0166 | PFAM: pyruvate carboxyltransferase; KEGG: afw:Anae109_2393 homocitrate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.936 |
Caur_0328 | leuC | Caur_0328 | Caur_0168 | PFAM: pyruvate carboxyltransferase; KEGG: afw:Anae109_2393 homocitrate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.838 |
Caur_0328 | leuC-2 | Caur_0328 | Caur_0329 | PFAM: pyruvate carboxyltransferase; KEGG: afw:Anae109_2393 homocitrate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 3-isopropylmalate dehydratase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.994 |
Caur_0328 | leuD | Caur_0328 | Caur_0169 | PFAM: pyruvate carboxyltransferase; KEGG: afw:Anae109_2393 homocitrate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.867 |
Caur_0328 | leuD-2 | Caur_0328 | Caur_0330 | PFAM: pyruvate carboxyltransferase; KEGG: afw:Anae109_2393 homocitrate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 3-isopropylmalate dehydratase, small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. | 0.994 |
Caur_0331 | Caur_0164 | Caur_0331 | Caur_0164 | PFAM: isocitrate/isopropylmalate dehydrogenase; KEGG: rrs:RoseRS_1057 3-isopropylmalate dehydrogenase. | TIGRFAM: acetolactate synthase, small subunit; PFAM: amino acid-binding ACT domain protein; KEGG: rrs:RoseRS_1967 acetolactate synthase, small subunit. | 0.840 |
Caur_0331 | Caur_0328 | Caur_0331 | Caur_0328 | PFAM: isocitrate/isopropylmalate dehydrogenase; KEGG: rrs:RoseRS_1057 3-isopropylmalate dehydrogenase. | PFAM: pyruvate carboxyltransferase; KEGG: afw:Anae109_2393 homocitrate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.945 |