Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
mdhMalate dehydrogenase, NAD-dependent; Catalyzes the reversible oxidation of malate to oxaloacetate. (309 aa)    
Predicted Functional Partners:
Caur_3809
KEGG: rrs:RoseRS_3488 citrate synthase I; TIGRFAM: citrate synthase I; PFAM: Citrate synthase; Belongs to the citrate synthase family.
  
 0.997
Caur_2080
PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; pyruvate ferredoxin/flavodoxin oxidoreductase; pyruvate flavodoxin/ferredoxin oxidoreductase domain protein; KEGG: rca:Rcas_4052 pyruvate flavodoxin/ferredoxin oxidoreductase domain protein.
  
  
 0.985
Caur_2895
TIGRFAM: isocitrate dehydrogenase, NADP-dependent; PFAM: CBS domain containing protein; isocitrate/isopropylmalate dehydrogenase; KEGG: rrs:RoseRS_0785 isocitrate dehydrogenase, NADP-dependent.
 
 0.966
Caur_1614
Malate dehydrogenase (oxaloacetate-decarboxylating); PFAM: amino acid-binding ACT domain protein; malic protein domain protein; malic protein NAD-binding; KEGG: rrs:RoseRS_2286 malate dehydrogenase (oxaloacetate-decarboxylating).
  
 0.963
Caur_3150
Aconitate hydratase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate.
  
 0.953
ppc
Phosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family.
     
 0.944
Caur_2969
KEGG: cvi:CV_3304 malate synthase A; TIGRFAM: malate synthase A; PFAM: malate synthase; Belongs to the malate synthase family.
   
 0.930
Caur_2355
PFAM: aminotransferase class I and II; KEGG: drm:Dred_1696 aminotransferase, class I and II.
  
 0.924
Caur_1375
TIGRFAM: succinic semialdehyde dehydrogenase; PFAM: Aldehyde Dehydrogenase_; KEGG: rxy:Rxyl_2905 succinate-semialdehyde dehydrogenase (NAD(P)+); Belongs to the aldehyde dehydrogenase family.
  
 0.919
Caur_3128
KEGG: rca:Rcas_1692 pyruvate kinase; TIGRFAM: pyruvate kinase; PFAM: Pyruvate kinase barrel; Pyruvate kinase alpha/beta; Belongs to the pyruvate kinase family.
  
 0.919
Your Current Organism:
Chloroflexus aurantiacus
NCBI taxonomy Id: 324602
Other names: C. aurantiacus J-10-fl, Chloroflexus aurantiacus ATCC 29366, Chloroflexus aurantiacus DSM 635, Chloroflexus aurantiacus J-10-fl, Chloroflexus aurantiacus str. J-10-fl, Chloroflexus aurantiacus strain J-10-fl
Server load: low (24%) [HD]