Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Caur_2135PFAM: 4Fe-4S ferredoxin iron-sulfur binding domain protein; protein of unknown function DUF224 cysteine-rich region domain protein; KEGG: rca:Rcas_4296 protein of unknown function DUF224 cysteine-rich region domain protein. (466 aa)    
Predicted Functional Partners:
Caur_2132
D-lactate dehydrogenase (cytochrome); PFAM: FAD linked oxidase domain protein; KEGG: rca:Rcas_4146 D-lactate dehydrogenase (cytochrome).
 
 0.998
Caur_2133
PFAM: FAD linked oxidase domain protein; KEGG: rrs:RoseRS_3362 FAD linked oxidase domain protein.
 
 0.997
Caur_1145
PFAM: FAD linked oxidase domain protein; KEGG: sus:Acid_1055 FAD linked oxidase domain protein.
 
 0.990
Caur_1144
PFAM: FAD linked oxidase domain protein; KEGG: rca:Rcas_4144 FAD linked oxidase domain protein.
 
 0.983
Caur_2134
D-lactate dehydrogenase (cytochrome); PFAM: FAD linked oxidase domain protein; KEGG: rrs:RoseRS_3360 D-lactate dehydrogenase (cytochrome).
  
 0.972
Caur_2969
KEGG: cvi:CV_3304 malate synthase A; TIGRFAM: malate synthase A; PFAM: malate synthase; Belongs to the malate synthase family.
  
 
 0.920
Caur_3889
TIGRFAM: isocitrate lyase; PFAM: isocitrate lyase and phosphorylmutase; KEGG: gka:GK0676 isocitrate lyase.
     
 0.909
Caur_0825
Glyoxylate reductase; PFAM: D-isomer specific 2-hydroxyacid dehydrogenase catalytic region; D-isomer specific 2-hydroxyacid dehydrogenase NAD-binding; KEGG: rrs:RoseRS_0216 glyoxylate reductase.
    
 0.907
Caur_2810
TIGRFAM: HAD-superfamily hydrolase, subfamily IA, variant 1; PFAM: Haloacid dehalogenase domain protein hydrolase; KEGG: mjl:Mjls_3357 HAD-superfamily hydrolase, subfamily IA, variant 1.
    
 0.903
mclA
HpcH/HpaI aldolase; Involved in the 3-hydroxypropionate cycle used for autotrophic carbon dioxide fixation, and in the glyoxylate assimilation cycle used to regenerate acetyl-CoA and produce pyruvate as universal precursor for biosynthesis. As a part of the 3-hydroxypropionate cycle, it catalyzes the cleavage of (S)-malyl-CoA to yield acetyl-CoA and glyoxylate. As part of the glyoxylate assimilation cycle, it catalyzes the condensation of glyoxylate with propionyl-CoA to yield (2R,3S)- beta-methylmalyl-CoA, and catalyzes the cleavage of (S)-citramalyl-CoA to yield acetyl-CoA and pyruva [...]
     
  0.900
Your Current Organism:
Chloroflexus aurantiacus
NCBI taxonomy Id: 324602
Other names: C. aurantiacus J-10-fl, Chloroflexus aurantiacus ATCC 29366, Chloroflexus aurantiacus DSM 635, Chloroflexus aurantiacus J-10-fl, Chloroflexus aurantiacus str. J-10-fl, Chloroflexus aurantiacus strain J-10-fl
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