Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
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gene neighborhood
gene co-occurrence
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cclPyruvate carboxyltransferase; Involved in the glyoxylate assimilation cycle used to regenerate acetyl-CoA and produce pyruvate as universal precursor for biosynthesis. Catalyzes the cleavage of (R)-citramalyl-CoA to yield acetyl-CoA and pyruvate. (317 aa)    
Predicted Functional Partners:
Caur_1565
PFAM: Enoyl-CoA hydratase/isomerase; KEGG: rca:Rcas_0977 enoyl-CoA hydratase/isomerase.
 
 0.944
Caur_2266
Formyl-CoA transferase; Involved in the 3-hydroxypropionate cycle used for autotrophic carbon dioxide fixation, and in the glyoxylate assimilation cycle used to regenerate acetyl-CoA and produce pyruvate as universal precursor for biosynthesis. Catalyzes the transfer of CoA moiety from succinyl-CoA to D-citramalate to yield citramalyl-CoA (By similarity).
 
  0.907
Caur_2034
Propionyl-CoA carboxylase; PFAM: carboxyl transferase; KEGG: rca:Rcas_0975 propionyl-CoA carboxylase.
 
 0.865
Caur_1350
Acetaldehyde dehydrogenase (acetylating); Catalyzes the conversion of acetaldehyde to acetyl-CoA, using NAD(+) and coenzyme A. Is the final enzyme in the meta-cleavage pathway for the degradation of aromatic compounds.
  
 
 0.849
Caur_2267
PFAM: regulatory protein GntR HTH; GntR domain protein; KEGG: rca:Rcas_3496 transcriptional regulator, GntR family.
       0.800
leuC
3-isopropylmalate dehydratase, large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.
  
  
 0.729
leuC-2
3-isopropylmalate dehydratase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate.
  
  
 0.729
leuB
3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.
  
 
 0.727
Caur_0331
PFAM: isocitrate/isopropylmalate dehydrogenase; KEGG: rrs:RoseRS_1057 3-isopropylmalate dehydrogenase.
  
 
 0.727
Caur_2264
5-oxoprolinase (ATP-hydrolyzing); PFAM: Hydantoinase/oxoprolinase; Hydantoinaseoxoprolinase domain protein; KEGG: rca:Rcas_3493 5-oxoprolinase (ATP-hydrolyzing).
 
  
 0.704
Your Current Organism:
Chloroflexus aurantiacus
NCBI taxonomy Id: 324602
Other names: C. aurantiacus J-10-fl, Chloroflexus aurantiacus ATCC 29366, Chloroflexus aurantiacus DSM 635, Chloroflexus aurantiacus J-10-fl, Chloroflexus aurantiacus str. J-10-fl, Chloroflexus aurantiacus strain J-10-fl
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