node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Apaf1 | LOC114138068 | ENSXCOP00000018145 | ENSXCOP00000004814 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | Ribosomal protein S27a. | 0.535 |
Apaf1 | LOC114149001 | ENSXCOP00000018145 | ENSXCOP00000023106 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | Ubiquitin-like domain-containing protein. | 0.435 |
Apaf1 | Tonsl | ENSXCOP00000018145 | ENSXCOP00000005946 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | Tonsoku-like, DNA repair protein. | 0.593 |
Apaf1 | uba52 | ENSXCOP00000018145 | ENSXCOP00000007438 | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | Ubiquitin A-52 residue ribosomal protein fusion product 1. | 0.435 |
ENSXCOP00000002822 | Mcm2 | ENSXCOP00000002822 | ENSXCOP00000010781 | FACT complex subunit SSRP1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] | DNA helicase; Belongs to the MCM family. | 0.804 |
ENSXCOP00000002822 | Tonsl | ENSXCOP00000002822 | ENSXCOP00000005946 | FACT complex subunit SSRP1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] | Tonsoku-like, DNA repair protein. | 0.667 |
ENSXCOP00000002822 | mms22l | ENSXCOP00000002822 | ENSXCOP00000022752 | FACT complex subunit SSRP1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] | MMS22-like, DNA repair protein. | 0.552 |
ENSXCOP00000006485 | ENSXCOP00000025031 | ENSXCOP00000006485 | ENSXCOP00000025031 | Aprataxin. | EMSY transcriptional repressor, BRCA2 interacting. | 0.639 |
ENSXCOP00000006485 | RNF8 | ENSXCOP00000006485 | ENSXCOP00000002835 | Aprataxin. | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] | 0.606 |
ENSXCOP00000006485 | Tonsl | ENSXCOP00000006485 | ENSXCOP00000005946 | Aprataxin. | Tonsoku-like, DNA repair protein. | 0.673 |
ENSXCOP00000025031 | ENSXCOP00000006485 | ENSXCOP00000025031 | ENSXCOP00000006485 | EMSY transcriptional repressor, BRCA2 interacting. | Aprataxin. | 0.639 |
ENSXCOP00000025031 | RNF8 | ENSXCOP00000025031 | ENSXCOP00000002835 | EMSY transcriptional repressor, BRCA2 interacting. | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] | 0.637 |
ENSXCOP00000025031 | Tonsl | ENSXCOP00000025031 | ENSXCOP00000005946 | EMSY transcriptional repressor, BRCA2 interacting. | Tonsoku-like, DNA repair protein. | 0.641 |
LOC114138068 | Apaf1 | ENSXCOP00000004814 | ENSXCOP00000018145 | Ribosomal protein S27a. | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | 0.535 |
LOC114138068 | LOC114149001 | ENSXCOP00000004814 | ENSXCOP00000023106 | Ribosomal protein S27a. | Ubiquitin-like domain-containing protein. | 0.993 |
LOC114138068 | Mcm2 | ENSXCOP00000004814 | ENSXCOP00000010781 | Ribosomal protein S27a. | DNA helicase; Belongs to the MCM family. | 0.676 |
LOC114138068 | RNF8 | ENSXCOP00000004814 | ENSXCOP00000002835 | Ribosomal protein S27a. | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] | 0.925 |
LOC114138068 | Tonsl | ENSXCOP00000004814 | ENSXCOP00000005946 | Ribosomal protein S27a. | Tonsoku-like, DNA repair protein. | 0.706 |
LOC114138068 | uba52 | ENSXCOP00000004814 | ENSXCOP00000007438 | Ribosomal protein S27a. | Ubiquitin A-52 residue ribosomal protein fusion product 1. | 0.999 |
LOC114149001 | Apaf1 | ENSXCOP00000023106 | ENSXCOP00000018145 | Ubiquitin-like domain-containing protein. | Apoptotic protease-activating factor 1; Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. | 0.435 |