STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ENSXCOP00000013804Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (237 aa)    
Predicted Functional Partners:
derl1
Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.
    
0.990
Amfr
Autocrine motility factor receptor b.
   
 0.964
ENSXCOP00000010100
SEL1L adaptor subunit of ERAD E3 ubiquitin ligase.
   
 0.954
ENSXCOP00000007670
Si:dkey-24p1.6.
   
 0.925
ENSXCOP00000002686
Ubiquitin recognition factor in ER associated degradation 1.
   
 
 0.921
ENSXCOP00000012750
Endoplasmic reticulum lectin 1.
    
 0.921
ENSXCOP00000026334
OS9 endoplasmic reticulum lectin.
    
 0.921
Derl2
Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family.
  
  
 
0.901
ENSXCOP00000002223
UBX domain protein 1.
    
 0.851
ENSXCOP00000019342
Zgc:136908; Belongs to the AAA ATPase family.
   
 0.840
Your Current Organism:
Xiphophorus couchianus
NCBI taxonomy Id: 32473
Other names: Limia couchiana, Monterrey platyfish, X. couchianus
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.