Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
LGAS_1700Guanylate kinase. (206 aa)    
Predicted Functional Partners:
xpt
Adenine/guanine phosphoribosyltransferase related PRPP-binding protein; Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis.
  
 
 0.950
guaA
GMP synthase (glutamine-hydrolyzing); Catalyzes the synthesis of GMP from XMP.
  
 
 0.949
gmk
Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.
  
  
 
0.926
LGAS_0857
Guanosine polyphosphate pyrophosphohydrolase/synthetase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.
  
 
 0.925
LGAS_0391
Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
   
 0.920
hpt
Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family.
  
 
 0.919
hpt-2
Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family.
  
 
 0.919
LGAS_1863
Deoxynucleoside kinase.
    
 0.914
guaC
IMP dehydrogenase/GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides; Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily.
    
 0.913
LGAS_1705
Ribonucleoside-diphosphate reductase class Ib beta subunit.
   
 
 0.909
Your Current Organism:
Lactobacillus gasseri
NCBI taxonomy Id: 324831
Other names: L. gasseri ATCC 33323 = JCM 1131, Lactobacillus gasseri ATCC 33323, Lactobacillus gasseri ATCC 33323 = JCM 1131, Lactobacillus gasseri DSM 20243, Lactobacillus gasseri NCDO 2233
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